ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023
Sex determination using color fundus parameters in older adults of Kumejima population study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 6 citations in OpenAlex.
- Association between fundus sex index and hypertension, diabetes mellitus, and smoking in the Kumejima study.Japanese journal of ophthalmology · 2026Observational
- Quantifying regional contributions to sex classification from fundus photographs via a two-stage attention-based deep learning approach.Scientific reports · 2026Article
- Distribution of axial length in Japanese children and adolescents aged 4 to 19 years.Japanese journal of ophthalmology · 2026Observational
- Refractive error and axial length prediction using fundus parameters of normal eyes in the Kumejima population study.Japanese journal of ophthalmology · 2025Observational
- Age prediction using fundus parameters of normal eyes from the Kumejima population study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Relationship between fundus sex index obtained using color fundus parameters and body height or axial length in the Kumejima population.Japanese journal of ophthalmology · 2024Observational
- Three-year changes in sex judgment using color fundus parameters in elementary school students.PloS one · 2023Observational
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
purposeDeep learning artificial intelligence can determine the sex using only fundus photographs. However, the factors used by deep learning to determine the sex are not visible. Therefore, the purpose of the study was to determine whether the sex of an older individual can be determined by regression analysis of their color fundus photographs (CFPs).
methodsForty-two parameters were analyzed by regression analysis using 1653 CFPs of normal subjects in the Kumajima study. The parameters included the mean values of red, green, and blue intensities; the tessellation fundus index; the optic disc ovality ratio; the papillomacular angle; and the retinal vessel angles. Finally, the L2 regularized binomial logistic regression was used to predict the sex using all the parameters, and the diagnostic ability was assessed through the leave-one-cross-validation.
resultsThe mean age of the 838 men and 815 women were 52.8 and 54.0 years, respectively. The ovality ratio and retinal artery angles in women were significantly smaller than that in men. The green intensity at all locations for the women were significantly higher than that of men (P < 0.001). The discrimination accuracy rate assessed by the area-under-the-curve was 80.4%.
conclusionsOur methods can determine the sex from the CFPs of the adult with an accuracy of 80.4%. The ovality ratio, retinal vessel angles, tessellation, and the green intensities of the fundus are important factors to identify the sex in individuals over 40 years old.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.