Evidence map›Paper›PMID 36856832›Full record

ArticleWorld journal of urology2023

Partial or radical nephrectomy for complex renal mass: a comparative analysis of oncological outcomes and complications from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group.

Clara Cerrato, Devin Patel, Riccardo Autorino, Giuseppe Simone, Bo Yang, Robert Uzzo, Francesco Porpiglia, Umberto Capitanio, James Porter, Alp Tuna Beksac and 20 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Urinary MicroRNAs as Biomarkers of Urological Cancers: A Systematic Review.International journal of molecular sciences · 2023
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The evolving management of small renal masses.Nature reviews. Urology · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Robotic surgery in urology: Recent advances.Asian journal of urology · 2023
    Article
  14. Review
  15. Article
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 17 institutions in 4 countries.

Clara CerratoDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Devin PatelDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Riccardo AutorinoDivision of Urology, VCU Health System, Richmond, USA.
Giuseppe SimoneDepartment of Urology, IRCCS-"Regina Elena" National Cancer Institute, Rome, Italy.
Bo YangDepartment of Urology, Changhai Hospital, Shanghai, China.
Robert UzzoDivision of Urology and Urologic Oncology, Fox Chase Cancer Center, Philadelphia, USA.
Francesco PorpigliaDepartment of Urology, University of Turin-San Luigi Gonzaga Hospital, Turin, Italy.
Umberto CapitanioUnit of Urology, IRCCS San Raffaele Scientific Institute, Urological Research Institute (URI) Division of Experimental Oncology, Vita-Salute San Raffaele, University, Milan, Italy.
James PorterSwedish Urology Group, Seattle, USA.
Alp Tuna BeksacGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, USA.
Andrea MinerviniDepartment of Urology, University of Florence, Florence, Italy.
Alessandro AntonelliDepartment of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Maria Angela CerrutoDepartment of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Clayton LauDivision of Urology and Urologic Oncology, City of Hope Medical Center, Duarte, USA.
Akbar AshrafiInstitute of Urology, University of Southern California Keck School of Medicine, Los Angeles, USA.
Daniel EunDepartment of Urology, Lewis Katz School of Medicine at Temple University, Philadelphia, USA.
Alexandre MottrieDepartment of Urology, OLV Hospital, Aalst, Belgium.
Carmen MirDepartment of Urology, IMED Hospitals, Valencia, Spain.
Margaret F MeagherDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Dhruv PuriDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Mimi NguyenDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Sohail DhanjiDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Franklin LiuDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA.
Savio D PandolfoDivision of Urology, VCU Health System, Richmond, USA.
Alexander KutikovDivision of Urology and Urologic Oncology, Fox Chase Cancer Center, Philadelphia, USA.
Francesco MontorsiUnit of Urology, IRCCS San Raffaele Scientific Institute, Urological Research Institute (URI) Division of Experimental Oncology, Vita-Salute San Raffaele, University, Milan, Italy.
Inderbir S GillInstitute of Urology, University of Southern California Keck School of Medicine, Los Angeles, USA.
Chandru SundaramDepartment of Urology, Indiana University Health, Indianapolis, USA.
Jihad KaoukGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, USA.
Ithaar H DerweeshDepartment of Urology, UC San Diego School of Medicine, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA, 92093-0987, USA. iderweesh@gmail.com.ORCID http://orcid.org/0000-0002-8673-0711
University of California San Diego · USUniversity of Verona · ITCleveland Clinic · USFox Chase Cancer Center · USUniversity of Southern California · USVita-Salute San Raffaele University · ITCity Of Hope National Medical Center · USIndiana University Health · USIstituti di Ricovero e Cura a Carattere Scientifico · ITOnze Lieve Vrouwziekenhuis Hospital · BERush University · USSeattle University · USSecond Military Medical University · CNTemple University · USUC San Diego Health System · USUniversity of Florence · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare outcomes of robotic-assisted partial nephrectomy (RAPN) and minimally invasive radical nephrectomy (MIS-RN) for complex renal masses (CRM).

methodsWe conducted a retrospective multicenter analysis of CRM patients who underwent MIS-RN and RAPN. CRM was defined as RENAL score 10-12. Primary outcome was overall survival (OS). Secondary outcomes were cancer-specific survival (CSS), recurrence, and complications. Multivariable analysis (MVA) and Kaplan-Meier Analysis (KMA) were used to analyze functional and survival outcomes for RN vs. PN by pathological stage.

results926 patients were analyzed (MIS-RN = 437/RAPN = 489; median follow-up 24.0 months). MVA demonstrated lack of transfusion (HR = 1.63, p = 0.005), low-grade (HR = 1.18, p = 0.018) and smaller tumor size (HR = 1.05, p < 0.001) were associated with OS. Younger age (HR = 1.01, p = 0.017), high-grade (HR = 1.18, p = 0.017), smaller tumor size (HR = 1.05, p < 0.001), and lack of transfusion (HR = 1.39, p = 0.038) were associated with CSS. Increasing tumor size (HR = 1.18, p < 0.001), high-grade (HR = 3.21, p < 0.001), and increasing age (HR = 1.02, p = 0.009) were independent risk factors for recurrence. Type of surgery was not associated with major complications (p = 0.094). For KMA of MIS-RN vs. RAPN for pT1, pT2 and pT3, 5-year OS was 85% vs. 88% (p = 0.078); 82% vs. 80% (p = 0.442) and 84% vs. 83% (p = 0.863), respectively. 5-year CSS was 98% for both procedures (p = 0.473); 94% vs. 92% (p = 0.735) and 91% vs. 90% (p = 0.581). 5-year non-CSS was 87% vs. 93% (p = 0.107); 87% for pT2 (p = 0.485) and 92% for pT3 for both procedures (p = 0.403).

conclusionRAPN in CRM is not associated with increased risk of complications or worsened oncological outcomes when compared to MIS-RN and may be preferred when clinically indicated.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsRobotic Surgical ProceduresHumansNephrectomyRetrospective StudiesTreatment OutcomeCarcinomaComplex renal massComplicationsPartial nephrectomyRadical nephrectomyRenal CellSurvival analysis

Identifiers

PMID36856832
OpenAlexW4322719666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.