Evidence map›Paper›PMID 36856800›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2023

Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents.

Bassam Abu Thaher, Ihab Al-Masri, Kanan Wahedy, Rami Morjan, Saeb Aliwaini, Iman Mahmoud Al Atter, Aayat Ahmed Elmabhouh, Areej Khaled Al Ibwaini, Saba Luay Alkhaldi, Basem Qeshta and 2 more

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bassam Abu ThaherFaculty of Science, Chemistry Department, Islamic University of Gaza, P.O. Box 108, Gaza, Palestine.
Ihab Al-MasriFaculty of Pharmacy, Al-Azhar University, Gaza, Palestine.
Kanan WahedyFaculty of Pharmacy, Al-Azhar University, Gaza, Palestine.
Rami MorjanFaculty of Science, Chemistry Department, Islamic University of Gaza, P.O. Box 108, Gaza, Palestine.
Saeb AliwainiDepartment of Biology and Biotechnology, Islamic University of Gaza, PO Box 108, Gaza, Palestine. siwini@iugaza.edu.ps.ORCID http://orcid.org/0000-0001-8795-201X
Iman Mahmoud Al AtterDepartment of Biology and Biotechnology, Islamic University of Gaza, PO Box 108, Gaza, Palestine.
Aayat Ahmed ElmabhouhDepartment of Biology and Biotechnology, Islamic University of Gaza, PO Box 108, Gaza, Palestine.
Areej Khaled Al IbwainiDepartment of Biology and Biotechnology, Islamic University of Gaza, PO Box 108, Gaza, Palestine.
Saba Luay AlkhaldiDepartment of Biology and Biotechnology, Islamic University of Gaza, PO Box 108, Gaza, Palestine.
Basem QeshtaFaculty of Science, Chemistry Department, Islamic University of Gaza, P.O. Box 108, Gaza, Palestine.
Claus JacobDivision of Bioorganic Chemistry, School of Pharmacy, Saarland University, D-66123, Saarbruecken, Germany.
Hans-Peter DeignerFaculty of Medical and Life Sciences, Hochschule Furtwangen (HFU), Jakob-Kienzle-Strasse 17, 78054, Villingen-Schwenningen, Germany. Hans-Peter.Deigner@hs-furtwangen.de.ORCID http://orcid.org/0000-0002-7745-0152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Four novel 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones derivatives (C1 to C4) have been designed, synthesized, and evaluated for their anticancer activity. The structure of compounds was characterized by IR,

Indexed as

Antineoplastic AgentsBreast NeoplasmsApoptosisBiological AssayCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorErbB ReceptorsFemaleHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipTriazinesAntineoplastic AgentsErbB ReceptorsTriazines[1,2,4]triazinoneArylBenzoimidazoleBreast cancerDockingEGFRPyridine

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.