Trial reportThe New England journal of medicine2023
Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence.
Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The New England journal of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03057431 (Randomized Double-blind Placebo-controlled Trial Assessing the Efficacy of Standard and Low Dose Hydrochlorothiazide Treatment in the Prevention of Recurrent Nephrolithiasis), which is not on this map. Cited by 71 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 8 pooled it
31.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Double-blind Placebo-controlled Trial Assessing the Efficacy of Standard and Low Dose Hydrochlorothiazide Treatment in the Prevention of Recurrent Nephrolithiasis
Who cites it
71 citing papers in PubMed, 8 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Thiazide and thiazide-like diuretics for kidney stones recurrence: a systematic review and network meta-analysis of randomised controlled trials.World journal of urology · 2025Pooled it
- Dent disease: clinical practice recommendations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Guideline
- SGLT2 inhibitors and nephrolithiasis risk: a meta-analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Pooled it
- The suggested dosage and course of thiazide diuretics on preventing recurrent urolithiasis: an upstate meta-analysis.World journal of urology · 2025Pooled it
- Pooled it
- Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Nature communications · 2023Pooled it
- Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk.JAMA network open · 2023Pooled it
- Brazilian Guidelines on evaluation and clinical management of Nephrolithiasis: Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Validation of an Automated CT Image Analysis in the Prevention of Urinary Stones with Hydration Trial.Journal of endourology · 2025Trial
- Empagliflozin in nondiabetic individuals with calcium and uric acid kidney stones: a randomized phase 2 trial.Nature medicine · 2025Trial
- Adjudication of Self-reported Symptomatic Stone Recurrence in the Prevention of Urinary Stones With Hydration Trial.Urology · 2024Trial
- Magnesium and kidney stones: a concise narrative review.Clinical kidney journal · 2026Review
- Baseline Urinary Calcium and the Efficacy of Thiazide Diuretics for Kidney Stone Prevention.The Journal of urology · 2026Article
- [Management of recurrent urolithiasis: indications for therapy escalation and discontinuation].Urologie (Heidelberg, Germany) · 2026Review
- The Role of Altered Mineral Metabolism in Kidney Stone Disease: Is Vitamin D the Key?American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Outcomes of Nephrolithiasis Care by Patients' Race: From a Statewide Quality Improvement Collaborative.Cureus · 2026Article
- Moving Mendelian Randomization From Traditional Risk Factors to Molecular Targets for Drug Development and Clinical Trials in Nephrology.Kidney international reports · 2026Review
- Prevention of Recurrent Kidney Stones: A CARI Guidelines Summary.Kidney international reports · 2026Article
- Risk Factors for Upper Urinary Tract Stone Recurrence: A Retrospective Study of 247 Patients.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Calcium Phosphate Nephrolithiasis: A Comprehensive Review.Kidney medicine · 2026Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 1 country.
Nasser A DhayatFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Olivier BonnyFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Beat RothFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Andreas ChristeFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Alexander RitterFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Nilufar MohebbiFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Nicolas FallerFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Lisa PellegriniFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Giulia BedinoFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Reto M VenzinFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Philipp GrosseFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Carina HüslerFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Irene KonethFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Christian BucherFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Rosaria Del GiornoFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Luca GabuttiFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Michael MayrFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Urs OdermattFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Florian BuchkremerFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Thomas ErnandezFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Catherine Stoermann-ChopardFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Daniel TetaFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Bruno VogtFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Marie RoumetFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Luca TamòFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.ORCID 0000-0001-7452-389X
Grazia M CereghettiFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Sven TrelleFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.
Daniel G FusterFrom the Departments of Nephrology and Hypertension (N.A.D., N.F., B.V., L.T., G.M.C., D.G.F.), Urology (B.R.), and Radiology (A.C.), Inselspital, Bern University Hospital, and CTU Bern (M.R., S.T.), University of Bern, Bern, Service of Nephrology, Lausanne University Hospital, University of Lausanne, Lausanne (O.B.), the Department of Nephrology, University Hospital Zurich, Zurich (A.R., N.M.), the Department of Nephrology, Regional Hospital Lugano (L.P., G.B.), and Università della Svizzera Italiana (R.D.G., L.G.), Lugano, the Department of Nephrology, Cantonal Hospital Graubünden, Chur (R.M.V., P.G.), the Department of Nephrology and Transplantation Medicine, Cantonal Hospital St. Gallen, St. Gallen (C.H., I.K., C.B.), the Department of Internal Medicine, Regional Hospital of Bellinzona, Bellinzona (R.D.G., L.G.), the Medical Outpatient Department, University Hospital Basel, University of Basel, Basel (M.M.), the Department of Nephrology, Luzerner Kantonsspital LUKS, Lucerne (U.O.), the Division of Nephrology, Dialysis, and Transplantation, Cantonal Hospital Aarau, Aarau (F.B.), the Department of Nephrology, University Hospital Geneva, University of Geneva, Geneva (T.E., C.S.-C.), and the Nephrology Service, Centre Hospitalier du Valais Romand, Sion (D.T.) - all in Switzerland.ORCID 0000-0001-7220-1803
University Hospital of Bern · CHUniversity of St.Gallen · CHUniversity of Geneva · CHUniversity of Basel · CHUniversity of Bern · CH
Funding
Inselspital, Universitätsspital Bern Intramural SupportSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 33IC30_166785
Abstract
backgroundNephrolithiasis is one of the most common conditions affecting the kidney and is characterized by a high risk of recurrence. Thiazide diuretic agents are widely used for prevention of the recurrence of kidney stones, but data regarding the efficacy of such agents as compared with placebo are limited. Furthermore, dose-response data are also limited.
methodsIn this double-blind trial, we randomly assigned patients with recurrent calcium-containing kidney stones to receive hydrochlorothiazide at a dose of 12.5 mg, 25 mg, or 50 mg once daily or placebo once daily. The main objective was to investigate the dose-response effect for the primary end point, a composite of symptomatic or radiologic recurrence of kidney stones. Radiologic recurrence was defined as the appearance of new stones on imaging or the enlargement of preexisting stones that had been observed on the baseline image. Safety was also assessed.
resultsIn all, 416 patients underwent randomization and were followed for a median of 2.9 years. A primary end-point event occurred in 60 of 102 patients (59%) in the placebo group, in 62 of 105 patients (59%) in the 12.5-mg hydrochlorothiazide group (rate ratio vs. placebo, 1.33; 95% confidence interval [CI], 0.92 to 1.93), in 61 of 108 patients (56%) in the 25-mg group (rate ratio, 1.24; 95% CI, 0.86 to 1.79), and in 49 of 101 patients (49%) in the 50-mg group (rate ratio, 0.92; 95% CI, 0.63 to 1.36). There was no relation between the hydrochlorothiazide dose and the occurrence of a primary end-point event (P = 0.66). Hypokalemia, gout, new-onset diabetes mellitus, skin allergy, and a plasma creatinine level exceeding 150% of the baseline level were more common among patients who received hydrochlorothiazide than among those who received placebo.
conclusionsAmong patients with recurrent kidney stones, the incidence of recurrence did not appear to differ substantially among patients receiving hydrochlorothiazide once daily at a dose of 12.5 mg, 25 mg, or 50 mg or placebo once daily. (Funded by the Swiss National Science Foundation and Inselspital; NOSTONE ClinicalTrials.gov number, NCT03057431.).
Indexed as
DiureticsHydrochlorothiazideKidney CalculiDose-Response Relationship, DrugDouble-Blind MethodHumansKidneyRecurrenceSodium Chloride Symporter InhibitorsDiureticsHydrochlorothiazideSodium Chloride Symporter Inhibitors
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NCT03057431ClinicalTrials.gov
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