Evidence map›Paper›PMID 36856574›Full record

ArticleDiabetes technology & therapeutics2023

Frequency and Detection of Insulin Infusion Site Failure in the Type 1 Diabetes Exchange Online Community.

Michael S Hughes, Julia L Douvas, Madison Layfield-Bryan, Luis E Blanco, John Clark Gray, Grzegorz Zapotoczny, Juan Espinoza, John H Wilcox, Rayhan A Lal

Open access · greenAbstract read
In one paragraph

Article in Diabetes technology & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Insulin Delivery Hardware: Pumps and Pens.Diabetes technology & therapeutics · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The Future of Automated Insulin Delivery Systems.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Michael S HughesDivision of Endocrinology, Gerontology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-3729-0350
Julia L DouvasPrinceton University, Princeton, New Jersey, USA.
Madison Layfield-BryanDiatech Diabetes, Inc., Memphis, Tennessee, USA.
Luis E BlancoDiatech Diabetes, Inc., Memphis, Tennessee, USA.
John Clark GrayDiatech Diabetes, Inc., Memphis, Tennessee, USA.
Grzegorz ZapotocznyDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.
Juan EspinozaDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID 0000-0003-0513-588X
John H WilcoxDiatech Diabetes, Inc., Memphis, Tennessee, USA.
Rayhan A LalDivision of Endocrinology, Gerontology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-8055-944X
University of Tennessee Health Science Center · USChildren's Hospital of Los Angeles · USPrinceton University · USStanford Medicine · USStanford University · US

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Holden T. Maecker · 2017 to 2026
$19.5M
Diabetes, Endocrinology and Metabolism Training GrantT32DK007217 · NIDDK · STANFORD UNIVERSITY · PI Justin Pierce Annes, David Matthew Maahs · 1987 to 2026
$7.2M
Training Research Leaders in Type 1 DiabetesK12DK122550 · NIDDK · STANFORD UNIVERSITY · PI MAAHS, DAVID MATTHEW · 2019 to 2023
$2.1M
The Optimal Pathway to Implanted Autonomous Insulin DeliveryK23DK122017 · NIDDK · STANFORD UNIVERSITY · PI LAL, RAYHAN · 2020 to 2024
$958k
NIDDK NIH HHS K12 DK122550NIDDK NIH HHS K23 DK122017NIDDK NIH HHS T32 DK007217
6 · The paper itself

Abstract

Insulin infusion site (IIS) failures are a weakness in insulin pump therapy. We examined experience with IIS failures among U.S. individuals with diabetes on insulin pump through survey distributed to the T1D Exchange Online Community. Demographic factors, IIS characteristics, and diabetes-related perceptions were assessed by logistic regression to determine odds of higher (≥1 per month) or lower (<1 per month) reported IIS failure frequency. IIS failures were common; 41.4% reported ≥1 per month. IIS failure is usually detected through development of hyperglycemia rather than pump alarm. No assessed demographic factor or IIS characteristic was predictive; however, higher odds of ≥1 failure per month were associated with feelings of burnout (odds ratios [OR] 1.489 [1.024, 2.165]) and considering pump discontinuation (OR 2.233 [1.455, 3.427]). IIS failures are frequent and unpredictable, typically require hyperglycemia for detection, and are associated with negative perceptions. More should be done toward preventing IIS failures and/or detecting them sooner.

Indexed as

Diabetes Mellitus, Type 1HyperglycemiaHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsInsulin, Regular, HumanHypoglycemic AgentsInsulinInsulin, Regular, HumanFailureInsulin infusion setInsulin infusion siteInsulin pumpPump malfunction

Identifiers

PMID36856574
PMCPMC10398731
OpenAlexW4322719149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.