Evidence map›Paper›PMID 36856550›Full record

SynthesisAnnals of medicine2023

Extracorporeal carbon dioxide removal for patients with acute respiratory failure: a systematic review and meta-analysis.

Zhifeng Zhou, Zhengyan Li, Chen Liu, Fang Wang, Ling Zhang, Ping Fu

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07161271 (Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07161271 recruitingnot on this mapstarted 2024, after this paper: background citation

Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating Efficacy and Safety

TypeobservationalSponsorHong Kong UniversityRan2024 to 2027Enrolled59ConditionsRespiratory Failure, ICU, Asthma (Diagnosis), ARDS
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. PaCOJournal of clinical medicine · 2026
    Review
  2. Review
  3. The role of extracorporeal COFrontiers in medicine · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Zhifeng ZhouDivision of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.ORCID 0000-0003-3160-589X
Zhengyan LiDivision of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Chen LiuDivision of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Fang WangDivision of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Ling ZhangDivision of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.ORCID 0000-0003-1155-4802
Ping FuDivision of Nephrology, Kidney Research Institute, West China Hospital of Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute respiratory failure (ARF) is a common clinical critical syndrome with substantial mortality. Extracorporeal carbon dioxide removal (ECCO

methodsElectronic databases (PubMed, Embase, Web of Science, and the Cochrane database) were searched from inception to 30 April 2022. Randomized controlled trials (RCTs) and observational studies that examined the following outcomes were included: mortality, length of hospital and ICU stay, intubation and tracheotomy rate, mechanical ventilation days, ventilator-free days (VFDs), respiratory parameters, and reported adverse events.

resultsFour RCTs and five observational studies including 1173 participants with ARF due to COPD or ARDS were included in this meta-analysis. Pooled analyses of related studies showed no significant difference in overall mortality between ECCO

conclusionsOur findings from both RCTs and observational studies did not confirm a significant beneficial effect of ECCO

Indexed as

Carbon DioxideRespiratory InsufficiencyDatabases, FactualHumansObservational Studies as TopicOxygenRenal DialysisCarbon DioxideOxygenacute respiratory failureExtracorporeal carbon dioxide removalmeta-analysismortality

Identifiers

PMID36856550
PMCPMC9980035
OpenAlexW4322718818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.