Evidence map›Paper›PMID 36856429›Full record

ArticleEnvironmental health perspectives2023

Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study.

Brenda Eskenazi, Robert B Gunier, Stephen Rauch, Katherine Kogut, Emily R Perito, Xenia Mendez, Charles Limbach, Nina Holland, Asa Bradman, Kim G Harley and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Brenda EskenaziCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Robert B GunierCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Stephen RauchCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Katherine KogutCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Emily R PeritoDepartment of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
Xenia MendezCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Charles LimbachMonterey County Health Department, Salinas, California, USA.
Nina HollandCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Asa BradmanCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Kim G HarleyCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.
Paul J MillsDepartment of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, USA.
Ana M MoraCenter for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.ORCID 0000-0002-2008-9714
Center for Environmental Health · USMonterey County Health Department · USUniversity of California, Merced · USUniversity of California San Diego · USUniversity of California, San Francisco · US

Funding

Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Effect of early life exposure to social adversity and pesticides on risk-taking behavior of 16-18 year olds: the CHAMACOS studyR01ES026994 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2016 to 2020
$3.9M
DDT & PBDE exposure, puberty onset and neurodevelopment in Mexican-American girlsR01ES017054 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2009 to 2013
$3.2M
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in UteroR01ES021369 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2013 to 2017
$3.1M
Early Adversity Shapes Adolescent Risk Behavior Trajectories in Mexican Americans (Diversity Supplement)R01DA035300 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DEARDORFF, JULIANNA · 2014 to 2018
$3.1M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Long-term sequelae of early life pesticide exposure in the CHAMACOS birth cohortUH3ES030631 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 2019 to 2020
$1000k
NIDA NIH HHS R01 DA035300NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R01 ES017054NIEHS NIH HHS R01 ES021369NIEHS NIH HHS R01 ES026994NIEHS NIH HHS R24 ES028529NIEHS NIH HHS U24 ES028529NIEHS NIH HHS UH3 ES030631
6 · The paper itself

Abstract

backgroundThe prevalence of liver disorders and metabolic syndrome has increased among youth. Glyphosate, the most widely used herbicide worldwide, could contribute to the development of these conditions.

objectiveWe aimed to assess whether lifetime exposure to glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), is associated with elevated liver transaminases and metabolic syndrome among young adults.

methodsWe conducted a prospective cohort study (

resultsUrinary AMPA at age 5 y was associated with elevated transaminases [relative risk (RR) per DISCUSSION: Childhood exposure to glyphosate and AMPA may increase risk of liver and cardiometabolic disorders in early adulthood, which could lead to more serious diseases later in life. https://doi.org/10.1289/EHP11721.

Indexed as

Metabolic SyndromeAdolescentAdultalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCase-Control StudiesChild, PreschoolFemaleGlyphosateHumansInflammationLiverOrganophosphonatesOrganophosphorus CompoundsPregnancyProspective StudiesYoung Adult1-aminomethylphosphonic acidalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acidaminomethylphosphonic acid (AMPA)GlyphosateOrganophosphonatesOrganophosphorus Compounds

Identifiers

PMID36856429
PMCPMC9976611
OpenAlexW4322719478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.