Evidence map›Paper›PMID 36856412›Full record

ArticleAmerican journal of respiratory cell and molecular biology2023

Estrogen Receptor-α Exerts Endothelium-Protective Effects and Attenuates Pulmonary Hypertension.

Andrea L Frump, Bakhtiyor Yakubov, Avram Walts, Amanda Fisher, Todd Cook, Naomi C Chesler, Tim Lahm

Open access · greenAbstract readLetter
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Signaling pathways and targeted therapy for pulmonary hypertension.Signal transduction and targeted therapy · 2025
    Review
  6. Effect of estrogen receptor α on cardiopulmonary adaptation to chronic developmental hypoxia in a rat model.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Andrea L FrumpIndiana University School of Medicine Indianapolis, Indiana.ORCID 0000-0002-5972-5079
Bakhtiyor YakubovIndiana University School of Medicine Indianapolis, Indiana.
Avram WaltsNational Jewish Health Denver, Colorado.
Amanda FisherIndiana University School of Medicine Indianapolis, Indiana.
Todd CookIndiana University School of Medicine Indianapolis, Indiana.
Naomi C CheslerUniversity of California, Irvine Irvine, California.ORCID 0000-0002-7612-5796
Tim LahmNational Jewish Health Denver, Colorado.ORCID 0000-0003-0007-6606
Indiana University School of MedicineNational Jewish Health · USUniversity of California, Irvine · USVeterans Health Administration · US

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
Mechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7M
The emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertensionR01HL164791 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea Lee Frump · 2022 to 2026
$3.8M
Mechanisms of right ventricle adaptation to pulmonary hypertensionR56HL134736 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2017 to 2017
$615k
BLRD VA I01 BX002042NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R01 HL164791NHLBI NIH HHS R56 HL134736NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Hypertension, PulmonaryHumansReceptors, EstrogenReceptors, Estrogen

Identifiers

PMID36856412
PMCPMC9989477
OpenAlexW4322720086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.