Evidence map›Paper›PMID 36856346›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2023

Transplantation and immigration: Comparing infectious complications and outcomes between foreign-born and US-born kidney transplant recipients in Minnesota.

Eloy E Ordaya, Megan Shaughnessy, Baila Elkin, Rachel L Husmann, Jacob C Stauffer, Elizabeth M Luengas, Bickey H Chang, Katelyn M Tessier, Patricia F Walker, William M Stauffer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Eloy E OrdayaDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Megan ShaughnessyDepartment of Medicine, Hennepin HealthCare, Minneapolis, Minnesota, USA.
Baila ElkinDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Rachel L HusmannDepartment of Medicine, Hennepin HealthCare, Minneapolis, Minnesota, USA.
Jacob C StaufferSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Elizabeth M LuengasDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Bickey H ChangDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Katelyn M TessierMasonic Cancer Center, Biostatistics Core, University of Minnesota, Minneapolis, Minnesota, USA.
Patricia F WalkerDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
William M StaufferDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota · USHennepin Healthcare Research Institute · USCleveland Clinic · USMayo Clinic in Florida · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494NCATS NIH HHS UL1TR002494NCI NIH HHS P30 CA077598NIH HHS P30 CA77598
6 · The paper itself

Abstract

backgroundForeign-born kidney transplant recipients (FBKTRs) are at increased risk for reactivation of latent infections that may impact outcomes. We aimed to compare the etiology of infections and outcomes between FBKTR and United States KTRs (USKTR).

methodsWe performed a retrospective study of patients who underwent kidney transplantation between January 1, 2014 and December 31, 2018 at two transplant centers in Minnesota. Frequency and etiology of infections as well as outcomes (graft function, rejection, and patient survival) at 1-year post-transplant between FBKTR and USKTR were compared.

resultsOf the 573 transplant recipients, 124 (21.6%) were foreign-born and 449 (78.4%) US-born. At least one infection occurred in 411 (71.7%) patients (38.2% bacterial, 55% viral, 9.4% fungal). Viral infections were more frequent in FBKTR, particularly BK viremia (38.7% vs. 21.2%, p < .001). No statistical differences were found for bacterial or fungal infections; no parasitic infections were identified in either group. No geographically-restricted infections were noted aside from a single case of Madura foot in a FBKTR. Rejection episodes were more common in USKTR (p = .037), but stable/improving graft function (p = .976) and mortality (p = .451) at 1-year posttransplantation were similar in both groups. After adjusting for covariates, previous transplantation was associated with a higher number of infections (IRR 1.35, 95% confidence intervals 1.05-1.73, p = .020).

conclusionAlthough viral infections were more frequent in FBKTR, overall frequency and etiology of most infections and outcomes were similar between FBKTR and USKTR suggesting that comprehensive transplant care is providing timely prevention, diagnosis, and treatment of latent infections in FBKTR.

Indexed as

Kidney TransplantationLatent InfectionEmigration and ImmigrationGraft RejectionHumansMinnesotaRetrospective StudiesTransplant Recipientsimmigration healthkidney transplantationtransplant infectious diseasestropical medicine

Identifiers

PMID36856346
PMCPMC10085839
OpenAlexW4322719416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.