Evidence map›Paper›PMID 36856215›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Shikonin induces hepatocellular carcinoma cell apoptosis by suppressing PKM2/PHD3/HIF-1

H Zhang, Z Chen, X Zhao, Q Huo, X Cheng

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

H ZhangAnhui Provincial Engineering Technology Research Center of Biochemical Drugs, Bengbu 233030, China.
Z ChenAnhui Provincial Engineering Technology Research Center of Biochemical Drugs, Bengbu 233030, China.
X ZhaoAnhui Provincial Engineering Technology Research Center of Biochemical Drugs, Bengbu 233030, China.
Q HuoAnhui Provincial Engineering Technology Research Center of Biochemical Drugs, Bengbu 233030, China.
X ChengAnhui Provincial Engineering Technology Research Center of Biochemical Drugs, Bengbu 233030, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the mechanism of shikonin-induced death of human hepatocellular carcinoma SMMC-7721 cells.

methodsCultured SMMC-7721 cells and normal hepatocytes (L-02 cells) were treated with 4, 8, or 16 μmol/L shikonin, and the changes in cell viability was assessed using MTT assay. The levels of ATP and lactic acid in the cell cultures were detected using commercial kits. Co-immunoprecipitation and immunofluorescence staining were used to determine the relationship among pyruvate kinase M2 (PKM2), prolyl hydroxylase 3 (PHD3), and hypoxia-inducible factor-1

resultsThe IC

conclusionsShikonin induces apoptosis of SMMC-7721 cells possibly by inhibiting aerobic glycolysis through the PKM2/PHD3/HIF-1

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAdenosine TriphosphateApoptosisbcl-2-Associated X ProteinCaspase 3HumansNaphthoquinonesProlyl HydroxylasesSignal TransductionAdenosine Triphosphatebcl-2-Associated X ProteinCaspase 3NaphthoquinonesProlyl Hydroxylasesshikoninapoptosishepatocellular carcinomahypoxia-inducible factor-1αprolyl hydroxylase 3pyruvate kinase M2shikonin

Identifiers

PMID36856215
PMCPMC9978725
OpenAlexW4322720364

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.