Evidence map›Paper›PMID 36856152›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Cognitive trajectories and incident dementia after a cardiovascular event in older adults.

Swarna Vishwanath, Ingrid Hopper, Rory Wolfe, Galina Polekhina, Christopher M Reid, Andrew M Tonkin, Anne M Murray, Raj C Shah, Elsdon Storey, Robyn L Woods and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Swarna VishwanathSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.ORCID 0000-0003-1140-5997
Ingrid HopperSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Galina PolekhinaSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Andrew M TonkinSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Anne M MurrayBerman Center for Outcomes & Clinical Research, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Raj C ShahDepartment of Family Medicine and the Rush Alzheimer's Disease Centre, Rush University Medical Centre, Chicago, Illinois, USA.
Elsdon StoreySchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
John McNeilSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Mark R NelsonSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Claire J StevesDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
Monash University · AUCurtin University · AUKing's College London · GBRush University Medical Center · USUniversity of Minnesota · USUniversity of Tasmania · AU

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682NIH HHS U01AG029824
6 · The paper itself

Abstract

introductionCardiovascular disease (CVD) is a recognized risk factor for dementia. Here we determined the extent to which an incident CVD event modifies the trajectory of cognitive function and risk of dementia.

methods19,114 adults (65+) without CVD or dementia were followed prospectively over 9 years. Incident CVD (fatal coronary heart disease, nonfatal myocardial infarction [MI], stroke, hospitalization for heart failure) and dementia (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) were adjudicated by experts.

resultsNine hundred twenty-two participants had incident CVD, and 44 developed dementia after CVD (4.9% vs. 4.4% for participants without CVD). Following a CVD event there was a short-term drop in processing speed (-1.97, 95% confidence interval [CI]: -2.57 to -1.41), but there was no significant association with longer-term processing speed. In contrast, faster declines in trajectories of global function (-0.56, 95% CI: -0.76 to -0.36), episodic memory (-0.10, 95% CI: -0.16 to -0.04), and verbal fluency (-0.19, 95% CI: -0.30 to -0.01) were observed. DISCUSSION: Findings highlight the importance of monitoring cognition after a CVD event.

Indexed as

Cardiovascular DiseasesCoronary DiseaseDementiaAgedCognitionHumansRisk Factorscardiovascular eventcognitive changecognitive domainsdementia incidenceolder adults

Identifiers

PMID36856152
PMCPMC10440246
OpenAlexW4322719441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.