Trial reportRenal failure2023
Randomized controlled trial of nalfurafine for refractory pruritus in hemodialysis patients.
Open access · goldAbstract readRandomized Controlled TrialMulticenter Study
In one paragraph
Trial report in Renal failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Chronic Kidney Disease-Associated Pruritus in Hemodialysis: Unraveling Mechanisms and Emerging Therapeutic Targets-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Efficacy and safety of different systemic drugs in the treatment of uremic pruritus among hemodialysis patients: a network meta-analysis based on randomized clinical trials.Frontiers in medicine · 2024Pooled it
- Difelikefalin in the treatment of hemodialysis patients with pruritus: a systematic review and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Article
- Article
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- Difelikefalin in Chinese patients with chronic kidney disease-associated pruritus.Clinical kidney journal · 2026Article
- Meta-Analysis of Randomized Controlled Trials on Gamma-Aminobutyric Acid Analogues and Opioid-Based Therapies for CKD-Associated Pruritus.Kidney international reports · 2025Article
- Pruritus in Uremic Patients: Approaches to Alleviating a Common Symptom in Chronic Kidney Disease.Life (Basel, Switzerland) · 2025Review
- The efficacy and safety of kappa opioid receptor (KOR) agonists in patients with uraemic pruritus: a systematic review and network meta-analysis.Clinical kidney journal · 2025Article
- CKD-associated pruritus in haemodialysis: a road map for diagnosis and treatment.Clinical kidney journal · 2025Review
- Efficacy and safety of HSK21542 for pruritus management in hemodialysis patients: a multicenter, randomized, double-blind, placebo-controlled trial.Frontiers in pharmacology · 2025Article
- Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine.Journal of medicinal chemistry · 2024Article
- Prevalence and Outcomes of Chronic Kidney Disease-Associated Pruritus: International Results from Peritoneal Dialysis Outcomes and Practice Patterns Study.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- [Clinical Research Progress on Using κ-Opioid Receptor Agonists to Treat Uremic Pruritus].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Review
- Identification and Management of CKD-Associated Pruritus: Current Insights.International journal of nephrology and renovascular disease · 2024Review
- Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients.Frontiers in nephrology · 2024Article
- Anxiety and depression in geriatric hemodialysis patients: factors that influence the border of diseases.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 20 institutions in 3 countries.
Ping ZhangKidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Shilong XiangKidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Bicheng LiuDepartment of Nephrology, ZhongDa Hospital, Southeast University, Chongqing, China.
Xiaohui WangDepartment of Nephrology, Fifth Hospital in Wuhan, Wuhan, China.
Xiaoping YangDepartment of Nephrology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, China.
Chaoyang YeDepartment of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zunsong WangDepartment of Nephrology, Shandong Province QianFoshan Hospital, Jinan, China.
Yanlin LiDepartment of Nephrology, Zhongshan Traditional Chinese Medicine Hospital, Guangzhou, China.
Li ZhouDepartment of Nephrology, West China Hospital of Sichuan University, Chengdu, China.
Caili WangDepartment of Nephrology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Hongbo LiDepartment of Nephrology, Wuhan No.1 Hospital, Wuhan, China.
Jian HuangDepartment of Nephrology, Jinhua Municipal Central Hospital, Jinhua, China.
Ai PengDepartment of Nephrology, Shanghai Tenth People's Hospital, Shanghai, China.
Xiaoping WangDepartment of Nephrology, The Central Hospital of Jinan, Jinan, China.
Deguang WangDepartment of Nephrology, The Second Hospital of Anhui Medical University, Hefei, China.
Jie XiaoDepartment of Nephrology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenli ChenDepartment of Nephrology, The Central Hospital of Wuhan, Wuhan, China.
Hong ChengDepartment of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Nan MaoDepartment of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Jianqin WangDepartment of Nephrology, Lanzhou University Second Hospital, Lanzhou, China.
Lin YangDepartment of Nephrology, Yichang Central People's Hospital, Yichang, China.
Jianghua ChenKidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Hangzhou Center for Disease Control and Prevention · CNBaotou Medical College · CNCapital Medical University · CNCentral Hospital of Wuhan · CNColorado Kidney Care · USFirst Affiliated Hospital of Chengdu Medical College · CNFirst Affiliated Hospital of Guangzhou Medical University · CNJinan Central Hospital · CNJinhua Central Hospital · CNLanzhou University · CNSecond Hospital of Anhui Medical University · CNShandong Provincial QianFoShan Hospital · CNShanghai Tenth People's Hospital · CNShihezi University · CNShuguang Hospital · CNWest China Hospital of Sichuan University · CNWuhan No.1 Hospital · CNWuhan University · CNYichang Central People's Hospital · CNZhongda Hospital Southeast University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Drug-Related Side Effects and Adverse ReactionsRenal Insufficiency, ChronicHumansKidneyMorphinansPruritusRenal DialysisSpiro CompoundsMorphinansSpiro CompoundsTRK 820chronic kidney disease-associated pruritusclinical trialhemodialysiskappa opioid receptor agonistNalfurafinerefractory
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.