Evidence map›Paper›PMID 36856106›Full record

ArticleJournal of musculoskeletal & neuronal interactions2023

MiRNA-206 Affects the Recovery of Sciatic Function by Stimulating BDNF Activity through the Down-regulation of Notch3 Expression.

Meng Wang, Shuang Wu, Jun Wang, Dandan Fan, Zhiyong Li, Shaohua Tian, Sining Yao, Hongyu Zhang, Hongwei Gao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Meng WangPost-graduation Education Office, College of General Practice and Continuing Education, Qiqihar Medical University, Qiqihar, China.
Shuang WuWard 5, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Jun WangAcademic Affairs Office, Qiqihar Medical University, Qiqihar, China.
Dandan FanWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Zhiyong LiWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Shaohua TianWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Sining YaoWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Hongyu ZhangWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Hongwei GaoWard 2, Department of Orthopedics, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects and mechanisms of microRNA 206 (miRNA-206) on neurological recovery through Notch receptor 3 (Notch3).

methodsThe sciatic functional index (SFI), nerve conduction velocity (NCV), tricipital muscle wet weight (TWW) and cross-sectional area of the muscular fiber, and grip strength of posterior limbs were detected by establishing a model of the sciatic nerve to evaluate the effect of sciatic nerve injury model. miRNA-206 expression in the model was detected by real-time quantitative polymerase chain reaction (qRT-PCR), to regulate the effects of miRNA-206 on the proliferation of gastrocnemius myocytes by Cell Counting Kit-8 (CCK-8).

resultsSFI of the model established by immediate epineurium suture after sciatic nerve resection was in the range of -150% to -100% and TWW, the average area of gastrocnemius myocytes, the NCV, and the grasping power of the hind limbs in the model were all lower than those in the normal group. And in the model, TWW, the average area of gastrocnemius myocytes, NCV, and grip strength of posterior limbs were lower in the normal group, which verified the successful establishment of the model.

conclusionOver-expression of miRNA-206 can down-regulate Notch3 expression, and then stimulate brain-derived neurotrophic factor (BDNF) activity to promote the repair and functional recovery of sciatic nerve injury.

Indexed as

MicroRNAsPeripheral Nerve InjuriesAnimalsBrain-Derived Neurotrophic FactorDown-RegulationHand StrengthHindlimbBrain-Derived Neurotrophic FactorMicroRNAsmiRNA-206Nerve Function RecoveryNotch3Sciatic Nerve Injury

Identifiers

PMID36856106
PMCPMC9976182
OpenAlexW4322718935

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.