Evidence map›Paper›PMID 36855631›Full record

ArticleFrontiers in immunology2023

Novel murine model reveals an early role for pertussis toxin in disrupting neonatal immunity to

Colleen J Sedney, Amanda Caulfield, Kaylan K Dewan, Uriel Blas-Machado, Maiya Callender, Nancy R Manley, Eric T Harvill

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Colleen J SedneyDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Amanda CaulfieldDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Kaylan K DewanDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Uriel Blas-MachadoDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Maiya CallenderDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Nancy R ManleyDepartment of Genetics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, United States.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
University of Georgia · USFranklin College · US

Funding

Protection against Bordetella pertussis transmission conferred by established and novel vaccinesR21AI159347 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
An air-liquid interface system to study Bordetella pertussis interactions with respiratory epitheliaR21AI171346 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2023 to 2024
$410k
NIAID NIH HHS R21 AI159347NIAID NIH HHS R21 AI171346
6 · The paper itself

Abstract

The increased susceptibility of neonates to specific pathogens has previously been attributed to an underdeveloped immune system. More recent data suggest neonates have effective protection against most pathogens but are particularly susceptible to those that target immune functions specific to neonates.

Indexed as

Bordetella pertussisWhooping CoughAnimalsDisease Models, AnimalKineticsMicePertussis ToxinPertussis Toxinimmunityneonatalpertussis toxinpertussis (whooping cough)T cells

Identifiers

PMID36855631
PMCPMC9968397
OpenAlexW4319601967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.