Evidence map›Paper›PMID 36855333›Full record

ArticleJournal of neurotrauma2023

Tau, β-Amyloid, and Glucose Metabolism Following Service-Related Traumatic Brain Injury in Vietnam War Veterans: The Australian Imaging Biomarkers and Lifestyle Study of Aging-Veterans Study (AIBL-VETS).

Tia L Cummins, Vincent Doré, Azadeh Feizpour, Natasha Krishnadas, Pierrick Bourgeat, Alby Elias, Fiona Lamb, Robert Williams, Malcolm Hopwood, Susan Landau and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Tia L CumminsDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Vincent DoréDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Azadeh FeizpourDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Natasha KrishnadasDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Pierrick BourgeatThe Australian eHealth Research Centre, CSIRO, Brisbane, Queensland, Australia.
Alby EliasDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Fiona LambDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Robert WilliamsThe Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
Malcolm HopwoodDepartment of Psychiatry, The University of Melbourne, Victoria, Australia.
Susan LandauHelen Wills Neuroscience Institute, University of California, Berkeley, California, USA.
Victor L VillemagneDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
Michael WeinerUniversity of California, San Francisco, California, USA.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Center for PET, Austin Health, Melbourne, Victoria, Australia.
The University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AUCommonwealth Scientific and Industrial Research Organisation · AUAustin Health · AUUniversity of California, Berkeley · USUniversity of California, San Francisco · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is common among military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 National Institute on Aging - Alzheimer's Association (NIA-AA) research framework, by measuring tau, β-amyloid, and glucose metabolism using positron emission tomography (PET) in veterans with service-related TBI. Seventy male Vietnam war veterans-40 with TBI (age 68.0 ± 2.5 years) and 30 controls (age 70.1 ± 5.3 years)-with no prior diagnosis of dementia or mild cognitive impairment underwent β-amyloid (

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrain Injuries, TraumaticCognitive Dysfunctiontau ProteinsVeteransAgedAgingAustralasian PeopleAustraliaBiomarkersCase-Control StudiesFluorodeoxyglucose F18GlucoseHumansLife StyleAmyloid beta-PeptidesBiomarkersFluorodeoxyglucose F18Glucosetau Proteins18F-FDGbrain imagingpositron emission tomographytautraumatic brain injuryVietnam veteransβ-amyloid

Identifiers

PMID36855333
PMCPMC10398748
OpenAlexW4322719663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.