ArticleInternational journal of geriatric psychiatry2023
It goes both ways: The relationship between anxiety and mild cognitive impairment.
Article in International journal of geriatric psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Emotion Dynamics in Young and Cognitively Diverse Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Adherence to the cMIND and AIDD diets and their associations with anxiety in older adults in China.Frontiers in nutrition · 2025Article
- Yoga an integrated mind body intervention for improvement in quality of life in individuals with Alzheimer's disease and their caregivers.Frontiers in aging · 2025Article
- Remission trajectories and cognitive function in hospitalized youth with depressive episodes.Frontiers in psychiatry · 2025Article
- Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID.BMC infectious diseases · 2024Article
- New insights on the link between Epstein‑Barr virus infection and cognitive decline in neurodegenerative diseases (Review).Experimental and therapeutic medicine · 2024Review
- Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
- Distinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults.Brain imaging and behavior · 2024Article
- Article
- Resilience in Mild Cognitive Impairment (MCI): Examining the Level and the Associations of Resilience with Subjective Wellbeing and Negative Affect in Early and Late-Stage MCI.Behavioral sciences (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the relationship between anxiety and mild cognitive impairment (MCI), and whether it is mediated by perceived stress, at the population level. METHOD AND
designIn a longitudinal study of 368 adults aged 65+ from a population-based cohort, we annually assessed anxiety symptoms (GAD-7), perceived stress (PSS-4), and ratings on the Clinical Dementia Rating (CDR®), where CDR = 0.5 was operationalized as MCI. Examining data from three consecutive assessment waves, we first determined the associations between anxiety at the first wave with MCI at the third wave, and vice versa. We then used mediation analyses to determine whether the pathways in both directions were mediated by perceived stress at the second wave, adjusting for demographics and other relevant covariates.
resultsWe confirmed significant bidirectional longitudinal associations between anxiety and MCI. Perceived stress was detected as a significant mediator for both pathways between anxiety and MCI, explaining 37.1% of the total effect (TE) of anxiety on incident MCI while conversely explaining 27.1% of the TE of MCI on anxiety.
conclusionsA bidirectional relationship with a 2-year lag between anxiety and MCI was mediated through perceived stress. Clinicians should be sensitive both to potential consequent anxiety when patients present with cognitive impairment, and to potential incipient MCI when the presenting complaint is anxiety. Managing stress may help mitigate adverse outcomes.
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