Evidence map›Paper›PMID 36855112›Full record

ReviewCancer cell international2023

The prognostic utility of preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with colorectal liver metastasis: a systematic review and meta-analysis.

Yanqing Li, Tianxiang Xu, Xin Wang, Xiangdong Jia, Meng Ren, Xiaoxia Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer cell international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanqing Li *Graduate School of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014000, China.
Tianxiang Xu *Abdominal Tumor Surgery, Center of Tumor, Inner Mongolia People's Hospital, Hohhot, 010017, China.
Xin WangGraduate School of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014000, China.
Xiangdong JiaAbdominal Tumor Surgery, Center of Tumor, Inner Mongolia People's Hospital, Hohhot, 010017, China.
Meng RenAbdominal Tumor Surgery, Center of Tumor, Inner Mongolia People's Hospital, Hohhot, 010017, China.
Xiaoxia WangIntensive Care Unit, Inner Mongolia People's Hospital, Hohhot, 010017, China. xiaoxiawang_2012@163.com.

Funding

Health Science and Technology Planning Project of Inner Mongolia Autonomous Region 201703011Health Science and Technology Planning Project of Inner Mongolia Autonomous Region 202201011Health Science and Technology Planning Project of Inner Mongolia Autonomous Region 202201012In-Hospital Fund of Inner Mongolia People's Hospital 2020YN06Natural Science Foundation of Inner Mongolia Autonomous Region 2018LH08002Natural Science Foundation of Inner Mongolia Autonomous Region 2019MS08085Scientific Research Start-up Fund for Doctoral of Inner Mongolia People's Hospital 2020BS06
6 · The paper itself

Abstract

The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM patients receiving surgery using meta-analysis. Data in Cochrane Library, PubMed, Embase, and Web of Science databases created before October 2022 were recruited. Meta-analysis was carried out with RevMan 5.3 and Stata16 software, and the primary outcome indicators included overall survival (OS), and secondary outcome indicators included disease-free survival (DFS) and relapse-free survival (RFS). The pooled risk ratio (HR) and 95% confidence interval (CI) for each outcome indicator were determined using random-effects models or fixed-effects models. The pooled odds ratio (OR) and corresponding 95% confidence intervals (CI) for NLR and clinicopathological characteristics were determined with a fixed-effects model. 18 papers published between 2008 and 2022 (3184 patients in total) were included. The pooled analysis found that high preoperative NLR was correlated with poor OS (multivariate HR = 1.83, 95% CI = 1.61-2.08, p < 0.01), DFS (multivariate HR = 1.78, 95% CI = 1.16-2.71, p < 0.01) and RFS (multivariate HR = 1.46, 95% CI = 1.15-1.85, p < 0.01), but NLR was not related to clinicopathological features of CRLM patients correlation. In conclusion, NLR is an independent risk factor for poor prognosis in patients with CRLM. More large-scale clinical researches are required in the future to demonstrate the inclusion of preoperative NLR as a prognostic indicator for CRLM patients to guide postoperative adjuvant chemotherapy.

Indexed as

Colorectal cancerLiver metastasisMeta-analysisNLRPrognosis

Identifiers

PMID36855112
PMCPMC9976405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.