Evidence map›Paper›PMID 36854738›Full record

ArticleScientific reports2023

Cdk5 mediates rotational force-induced brain injury.

Alan Umfress, Ayanabha Chakraborti, Suma Priya Sudarsana Devi, Raegan Adams, Daniel Epstein, Adriana Massicano, Anna Sorace, Sarbjit Singh, M Iqbal Hossian, Shaida A Andrabi and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Alan UmfressDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Ayanabha ChakrabortiDepartment of Translational Neuroscience, University of Arizona College of Medicine in Phoeni, Biomedical Sciences Partnership Bldg, Phoenix, AZ, 85004 , USA.
Suma Priya Sudarsana DeviDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Raegan AdamsDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Daniel EpsteinDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Adriana MassicanoDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Anna SoraceDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sarbjit SinghEppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, NE, USA.
M Iqbal HossianDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.
Shaida A AndrabiDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL, USA.
David K CrossmanDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Nilesh KumarDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
M Shahid MukhtarDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Huiyang LuoKaragozian & Case, Inc., Glendale, CA, USA.
Claire SimpsonCell Signaling Technology, Danvers, MA, USA.
Kathryn AbellCell Signaling Technology, Danvers, MA, USA.
Matthew StokesCell Signaling Technology, Danvers, MA, USA.
Thorsten WiederholdCell Signaling Technology, Danvers, MA, USA.
Charles RosenOSF Healthcare Illinois Neurological Institute, Peoria, IL, USA.
Hongbing LuDepartment of Mechanical Engineering, University of Texas at Dallas, Dallas, TX, USA.
Amarnath NatarajanEppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical Center, Omaha, NE, USA.
James A BibbDepartment of Translational Neuroscience, University of Arizona College of Medicine in Phoeni, Biomedical Sciences Partnership Bldg, Phoenix, AZ, 85004 , USA. jbibb@arizona.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
UAB Research Training Program in Neurobiology of Cognition and Cognitive DisordersT32NS061788 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Farah Dominique Lubin · 2008 to 2026
$4.5M
The Role of Cdk5 in StrokeR01NS073855 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI BIBB, JAMES A · 2012 to 2017
$1.7M
NCI NIH HHS P30 CA013148NIDA NIH HHS P30 DA018343NIH HHS DA018343NIH HHS NS073855NINDS NIH HHS NS061788NINDS NIH HHS R01 NS073855NINDS NIH HHS T32 NS061788
6 · The paper itself

Abstract

Millions of traumatic brain injuries (TBIs) occur annually. TBIs commonly result from falls, traffic accidents, and sports-related injuries, all of which involve rotational acceleration/deceleration of the brain. During these injuries, the brain endures a multitude of primary insults including compression of brain tissue, damaged vasculature, and diffuse axonal injury. All of these deleterious effects can contribute to secondary brain ischemia, cellular death, and neuroinflammation that progress for weeks, months, and lifetime after injury. While the linear effects of head trauma have been extensively modeled, less is known about how rotational injuries mediate neuronal damage following injury. Here, we developed a new model of repetitive rotational head trauma in rodents and demonstrated acute and prolonged pathological, behavioral, and electrophysiological effects of rotational TBI (rTBI). We identify aberrant Cyclin-dependent kinase 5 (Cdk5) activity as a principal mediator of rTBI. We utilized Cdk5-enriched phosphoproteomics to uncover potential downstream mediators of rTBI and show pharmacological inhibition of Cdk5 reduces the cognitive and pathological consequences of injury. These studies contribute meaningfully to our understanding of the mechanisms of rTBI and how they may be effectively treated.

Indexed as

Brain Injuries, TraumaticCraniocerebral TraumaCyclin-Dependent Kinase 5AnimalsBrainBrain InjuriesRatsCyclin-Dependent Kinase 5

Identifiers

PMID36854738
PMCPMC9974974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.