Evidence map›Paper›PMID 36854652›Full record

SynthesisBritish journal of sports medicine2023

Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.

Leandro Garcia, Matthew Pearce, Ali Abbas, Alexander Mok, Tessa Strain, Sara Ali, Alessio Crippa, Paddy C Dempsey, Rajna Golubic, Paul Kelly and 8 more

Registry-linked trialOpen access · hybridAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of sports medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883591 (Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty), which is not on this map. Cited by 142 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed, 12 pooled it
41.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06883591 completednot on this mapstarted 2025, after this paper: background citation

Physical Activity in Patients After Resurfacing and Total Hip Arthroplasty: an Observational Follow-up Study 15 Years After Surgery.

TypeobservationalSponsorRijnstate HospitalRan2025 to 2026Enrolled32ConditionsTotal Hip Arthroplasty (THA), Accelerometers, Resurfacing Hip Arthroplasty
3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 12 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Pooled it
  2. Exercise and pathologic complete response to cancer treatment: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
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  13. Trial
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  15. A Co-clinical Trial of Exercise Therapy in Breast Cancer Prevention.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
  16. Effects of a Physical Activity mHealth Intervention (Fit2Thrive) on WCRF/AICR Cancer Prevention Recommendations among Breast Cancer Survivors: A Secondary Data Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Trial
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  19. The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  20. Article

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 6 countries.

Leandro Garcia *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0001-5947-2617
Matthew Pearce *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0003-3718-7502
Ali Abbas *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Alexander Mok *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Tessa Strain *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0002-7086-1047
Sara AliUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Alessio CrippaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Paddy C DempseyMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Rajna GolubicMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Paul KellyPhysical Activity for Health Research Centre, University of Edinburgh Institute for Sport, Physical Education and Health Sciences, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1946-9848
Yvonne LairdSydney School of Public Health, Prevention Research Collaboration, The University of Sydney, Sydney, New South Wales, Australia.
Eoin McNamaraMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Samuel MooreUniversity of Cambridge School of Clinical Medicine, Cambridge, UK.
Thiago Herick de SaCenter for Epidemiological Research in Nutrition and Health, University of Sao Paulo, Sao Paulo, Brazil.
Andrea D SmithMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Katrien WijndaeleMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
James Woodcock *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Soren Brage *MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK soren.brage@mrc-epid.cam.ac.uk.ORCID http://orcid.org/0000-0002-1265-7355
University of Cambridge · GBAgency for Science, Technology and Research · SGEconomic and Social Research Institute · IEKarolinska Institutet · SEQueen's University Belfast · GBThe University of Sydney · AUUniversidade de São Paulo · BRUniversity of Edinburgh · GBUniversity of Leicester · GB

Funding

Medical Research Council MC_UU_00006/4Medical Research Council MC_UU_00006/5Medical Research Council MC_UU_12015/3Medical Research Council MR/K023187/1Medical Research Council MR/K025147/1Medical Research Council MR/P024408/1Medical Research Council MR/P02663X/1Wellcome Trust
6 · The paper itself

Abstract

objectiveTo estimate the dose-response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population.

designSystematic review and cohort-level dose-response meta-analysis. DATA SOURCES: PubMed, Scopus, Web of Science and reference lists of published studies. ELIGIBILITY CRITERIA: Prospective cohort studies with (1) general population samples >10 000 adults, (2) ≥3 physical activity categories, and (3) risk measures and CIs for all-cause mortality or incident total cardiovascular disease, coronary heart disease, stroke, heart failure, total cancer and site-specific cancers (head and neck, myeloid leukaemia, myeloma, gastric cardia, lung, liver, endometrium, colon, breast, bladder, rectum, oesophagus, prostate, kidney).

results196 articles were included, covering 94 cohorts with >30 million participants. The evidence base was largest for all-cause mortality (50 separate results; 163 415 543 person-years, 811 616 events), and incidence of cardiovascular disease (37 results; 28 884 209 person-years, 74 757 events) and cancer (31 results; 35 500 867 person-years, 185 870 events). In general, higher activity levels were associated with lower risk of all outcomes. Differences in risk were greater between 0 and 8.75 marginal metabolic equivalent of task-hours per week (mMET-hours/week) (equivalent to the recommended 150 min/week of moderate-to-vigorous aerobic physical activity), with smaller marginal differences in risk above this level to 17.5 mMET-hours/week, beyond which additional differences were small and uncertain. Associations were stronger for all-cause (relative risk (RR) at 8.75 mMET-hours/week: 0.69, 95% CI 0.65 to 0.73) and cardiovascular disease (RR at 8.75 mMET-hours/week: 0.71, 95% CI 0.66 to 0.77) mortality than for cancer mortality (RR at 8.75 mMET-hours/week: 0.85, 95% CI 0.81 to 0.89). If all insufficiently active individuals had achieved 8.75 mMET-hours/week, 15.7% (95% CI 13.1 to 18.2) of all premature deaths would have been averted.

conclusionsInverse non-linear dose-response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults.

Indexed as

Cardiovascular DiseasesNeoplasmsAdultChronic DiseaseExerciseFemaleHumansMaleProspective Studiesepidemiologyhealthmeta-analysisnoncommunicable diseasesphysical activity

Identifiers

PMID36854652
PMCPMC10423495
OpenAlexW4322621958

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.