Evidence map›Paper›PMID 36854145›Full record

ArticleACS chemical biology2023

Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant

Eric Bryan, Edgar Ferrer-González, Hye Yeon Sagong, Junso Fujita, Lilly Mark, Malvika Kaul, Edmond J LaVoie, Hiroyoshi Matsumura, Daniel S Pilch

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Eric BryanDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States.
Edgar Ferrer-GonzálezDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States.ORCID 0000-0001-6188-4979
Hye Yeon SagongDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States.
Junso FujitaDepartment of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0003-1273-3917
Lilly MarkTAXIS Pharmaceuticals, Inc., 9 Deer Park Drive, Suite J-15, Monmouth Junction, New Jersey 08852, United States.
Malvika KaulDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States.
Edmond J LaVoieDepartment of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, New Jersey 08854, United States.
Hiroyoshi MatsumuraDepartment of Biotechnology, College of Life Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Shiga 525-8577, Japan.ORCID 0000-0003-0361-3796
Daniel S PilchDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-0113-0849
Rutgers, The State University of New Jersey · USRitsumeikan University · JPThe University of Osaka · JP

Funding

Development of New Antibiotics Against Multidrug-Resistant Staphylococcus aureusR01AI118874 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI PILCH, DANIEL S · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI118874
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusProdrugsStaphylococcal InfectionsAnimalsAnti-Bacterial AgentsBacterial ProteinsBenzamidesCytoskeletal ProteinsLinezolidMammalsMethicillinMiceMicrobial Sensitivity TestsStaphylococcus aureusThiazolesVancomycinAnti-Bacterial AgentsBacterial ProteinsbenzamideBenzamidesCytoskeletal ProteinsLinezolidMethicillinProdrugsThiazolesTXA707TXA709Vancomycin

Identifiers

PMID36854145
PMCPMC10274580
OpenAlexW4322623277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.