Evidence map›Paper›PMID 36854077›Full record

ArticleJCO global oncology2023

Cancer Genetic Services in a Low- to Middle-Income Country: Cross-Sectional Survey Assessing Willingness to Undergo and Pay for Germline Genetic Testing.

Prisca O Adejumo, Toyin I G Aniagwu, Olutosin A Awolude, Babatunde Adedokun, Makayla Kochheiser, Anthonia Sowunmi, Abiodun Popoola, Oladosu Ojengbede, Dezheng Huo, Olufunmilayo I Olopade

Open access · goldAbstract read
In one paragraph

Article in JCO global oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Prisca O AdejumoDepartment of Nursing, College of Medicine, University of Ibadan, Nigeria.ORCID 0000-0003-3065-8308
Toyin I G AniagwuSchool of Occupational Health Nursing, University College Hospital, Ibadan, Nigeria.ORCID 0000-0001-6302-303X
Olutosin A AwoludeDepartment of Obstetrics and Gynaecology, University College Hospital, Ibadan, Oyo, Nigeria.ORCID 0000-0003-3365-0256
Babatunde AdedokunCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, IL.ORCID 0000-0002-6893-6468
Makayla KochheiserCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, IL.
Anthonia SowunmiLagos State University Teaching Hospital, Lagos, Nigeria.ORCID 0000-0001-6565-7116
Abiodun PopoolaLagos State University Teaching Hospital, Lagos, Nigeria.
Oladosu OjengbedeCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.
Dezheng HuoDepartment of Public Health Sciences, The University of Chicago, Chicago, IL.ORCID 0000-0002-4041-1678
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics & Global Health, Department of Medicine, The University of Chicago, Chicago, IL.ORCID 0000-0002-9936-1599
University of Chicago · USLagos State University Teaching Hospital · NGUniversity College Hospital, Ibadan · NGUniversity of Ibadan · NGChicago Department of Public Health · US

Funding

Polygenic Risk Prediction of Breast Cancer for Women of African DescentR01CA228198 · NCI · UNIVERSITY OF CHICAGO · PI Dezheng Huo · 2018 to 2026
$3.9M
NCI NIH HHS R01 CA228198
6 · The paper itself

Abstract

purposeCancer genetic testing (CGT), a pathway to personalized medicine, is also being embraced in Nigeria. However, little is known about the influence of demographics and perceptions on individuals' willingness to access and pay for CGT. This study assessed patients' willingness to undergo CGT in southwest Nigeria as a catalyst for sustainable Cancer Risk Management Program.

methodsThis was a cross-sectional study using semistructured questionnaire to interview 362 patients with cancer and 10 referred first-degree relatives between July 2018 and February 2020. Participants from three Nigerian teaching hospitals-University College Hospital, Ibadan, Lagos State University Teaching Hospital, Lagos, and Lagos University Teaching Hospital, Lagos, received genetic counseling and had subsequent CGT. Primary outcomes were willingness to undergo CGT in determining cancer risk and the willingness to pay for it. Ethical approval was from appropriate ethics committees of participating hospitals. Data were analyzed with SPSS version 22. Univariate comparison of categorical variables was performed by χ

resultsThe participants from University College Hospital (56.2%), Lagos State University Teaching Hospital (26.3%), and Lagos University Teaching Hospital (17.5%) were mostly female (98.4%). Mean age was 48.8 years ± 11.79. Three hundred twenty-two (86.6%) patients and first-degree relatives were willing to take the test, of whom 231 (71.1%) were willing to pay for it. more than half (53.6%) of the participants were willing to pay between N10,000 and N30,000, which is less than $100 US dollars. Sociodemographic variables and willingness to test showed no association (

conclusionLearning clinically relevant details toward cancer prevention informs health-related decisions in patients and relatives, a motivator for willingness to pay for genetic testing in low- and middle-income countries. Increased awareness may influence outcomes of cancer risk management.

Indexed as

Genetic ServicesNeoplasmsCross-Sectional StudiesFemaleGenetic TestingGerm CellsHumansMaleMiddle AgedNigeria

Identifiers

PMID36854077
PMCPMC10166413
OpenAlexW4322624233

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.