Evidence map›Paper›PMID 36854044›Full record

ArticleACS applied materials & interfaces2023

Composite Graded Melt Electrowritten Scaffolds for Regeneration of the Periodontal Ligament-to-Bone Interface.

Nasim Golafshan, Miguel Castilho, Arwa Daghrery, Morteza Alehosseini, Tom van de Kemp, Konstantinos Krikonis, Mylene de Ruijter, Renan Dal-Fabbro, Alireza Dolatshahi-Pirouz, Sarit B Bhaduri and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Recent advances in additive manufacturing of patient-specific devices for dental and maxillofacial rehabilitation.Dental materials : official publication of the Academy of Dental Materials · 2024
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Nasim GolafshanDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.
Miguel CastilhoDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.ORCID 0000-0002-4269-5889
Arwa DaghreryDepartment of Restorative Dental Sciences, School of Dentistry, Jazan University, Jazan 45142, Kingdom of Saudi Arabia.
Morteza AlehosseiniTechnical University of Denmark, Department of Health Technology, Lyngby 2800 Kgs, Denmark.
Tom van de KempDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.
Konstantinos KrikonisDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.
Mylene de RuijterDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.
Renan Dal-FabbroDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104, United States.ORCID 0000-0002-4125-8441
Alireza Dolatshahi-PirouzTechnical University of Denmark, Department of Health Technology, Lyngby 2800 Kgs, Denmark.
Sarit B BhaduriDepartment of Mechanical, Industrial and Manufacturing Engineering, University of Toledo, Toledo, Ohio 43606, United States.
Marco C BottinoDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104, United States.ORCID 0000-0001-8740-2464
Jos MaldaDepartment of Orthopaedics, University Medical Center Utrecht, Utrecht University, Utrecht 3508 GA, The Netherlands.ORCID 0000-0002-9241-7676
Utrecht University · NLUniversity of Michigan · USTechnical University of Denmark · DKU.S. National Science Foundation · US

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
NIDCR NIH HHS R01 DE031476
6 · The paper itself

Abstract

Periodontitis is a ubiquitous chronic inflammatory, bacteria-triggered oral disease affecting the adult population. If left untreated, periodontitis can lead to severe tissue destruction, eventually resulting in tooth loss. Despite previous efforts in clinically managing the disease, therapeutic strategies are still lacking. Herein, melt electrowriting (MEW) is utilized to develop a compositionally and structurally tailored graded scaffold for regeneration of the periodontal ligament-to-bone interface. The composite scaffolds, consisting of fibers of polycaprolactone (PCL) and fibers of PCL-containing magnesium phosphate (MgP) were fabricated using MEW. To maximize the bond between bone (MgP) and ligament (PCL) regions, we evaluated two different fiber architectures in the interface area. These were a crosshatch pattern at a 0/90° angle and a random pattern. MgP fibrous scaffolds were able to promote

Indexed as

Periodontal LigamentPeriodontitisAnimalsBone and BonesBone RegenerationMagnesium CompoundsOsteogenesisPhosphatesPolyestersRatsTissue EngineeringTissue ScaffoldsMagnesium Compoundsmagnesium phosphatePhosphatesPolyestersbone regenerationinterfacemelt electrowritingperiodontal ligamentperiodontitis

Identifiers

PMID36854044
PMCPMC11022588
OpenAlexW4322624058

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.