Evidence map›Paper›PMID 36853925›Full record

ArticleEnvironmental science & technology2023

Efficacy of Grignard Pure to Inactivate Airborne Phage MS2, a Common SARS-CoV-2 Surrogate.

Grishma Desai, Gurumurthy Ramachandran, Emanuel Goldman, William Esposito, Antony Galione, Altaf Lal, Toni K Choueiri, Andre Fay, William Jordan, Donald W Schaffner and 3 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Managing infectious aerosols to counter engineered pandemics: Current recommendations and future research.Risk analysis : an official publication of the Society for Risk Analysis · 2025
    Guideline
  2. Inactivation of airborne pathogen surrogates by triethylene glycol.Applied and environmental microbiology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Impact of test methodology on the efficacy of triethylene glycol (Grignard Pure) against bacteriophage MS2.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2023
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Grishma DesaiGrignard Company, LLC, Rahway, New Jersey 07065, United States.
Gurumurthy RamachandranDepartment of Environmental Health and Engineering, Johns Hopkins Education and Research Center for Occupational Safety and Health, Bloomberg School of Public Health, Whiting School of Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Emanuel GoldmanDepartment of Microbiology, Biochemistry, and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, New Jersey 07103, United States.ORCID 0000-0002-6748-0884
William EspositoFounder, Ambient Group, Inc., New York, New York 10018, United States.
Antony GalioneDepartment of Pharmacology, University of Oxford, Oxford OX1 3QT, United Kingdom.
Altaf LalFormer Chief, Molecular Vaccine Section, CDC. Former Health Attaché and HHS Regional Representative for South Asia, Former US FDA Country Director - India, Atlanta, Georgia 30345, United States.
Toni K ChoueiriDana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, United States.
Andre FayPontifícia Universidade Católica do Rio Grande do Sul, School of Medicine, Porto Alegre, Rio Grande do Sul 90619-900, Brazil.
William JordanFormer Deputy Director, Office of Pesticide Programs, Environmental Protection Agency, William Jordan Consulting, Washington, District of Columbia 20016, United States.
Donald W SchaffnerDepartment of Food Science, School of Environmental and Biological Sciences, Rutgers, The State University of NJ, New Brunswick, New Jersey 08902, United States.
Jack CaravanosClinical Professor of Environmental Public Health Services, New York University, New York, New York 10012, United States.
Etienne GrignardFounder, CEO, Grignard Pure, LLC, Rahway, New Jersey 07065, United States.
Gediminas MainelisDepartment of Environmental Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of NJ, New Brunswick, New Jersey 08901, United States.ORCID 0000-0002-5837-0413

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
NIEHS NIH HHS P30 ES005022
6 · The paper itself

Abstract

Grignard Pure (GP) is a unique and proprietary blend of triethylene glycol (TEG) and inert ingredients designed for continuous antimicrobial treatment of air. TEG has been designated as a ″Safer Chemical" by the US EPA. GP has already received approval from the US EPA under its Section 18 Public Health Emergency Exemption program for use in seven states. This study characterizes the efficacy of GP for inactivating MS2 bacteriophage─a nonenveloped virus widely used as a surrogate for SARS-CoV-2. Experiments measured the decrease in airborne viable MS2 concentration in the presence of different concentrations of GP from 60 to 90 min, accounting for both natural die-off and settling of MS2. Experiments were conducted both by introducing GP aerosol into air containing MS2 and by introducing airborne MS2 into air containing GP aerosol. GP is consistently able to rapidly reduce viable MS2 bacteriophage concentration by 2-3 logs at GP concentrations of 0.04-0.5 mg/m

Indexed as

Anti-Infective AgentsCOVID-19HumansLevivirusRespiratory Aerosols and DropletsSARS-CoV-2Anti-Infective Agentsaerosol inactivationaerosol transmissionairborne transmissionCOVID-19infectious diseasesMS2 bacteriophageSARs-CoV-2triethylene glycol

Identifiers

PMID36853925
PMCPMC10001433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.