Evidence map›Paper›PMID 36853481›Full record

ArticleNeurochemical research2023

ATF6β Deficiency Elicits Anxiety-like Behavior and Hyperactivity Under Stress Conditions.

Takashi Tanaka, Dinh Thi Nguyen, Nichakarn Kwankaew, Megumi Sumizono, Reika Shinoda, Hiroshi Ishii, Mika Takarada-Iemata, Tsuyoshi Hattori, Seiichi Oyadomari, Nobuo Kato and 2 more

Abstract read
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In one paragraph

Article in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Takashi TanakaStudies in Rehabilitation, Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan.
Dinh Thi NguyenDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan.
Nichakarn KwankaewDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan.
Megumi SumizonoDepartment of Rehabilitation, Kyushu University of Nursing and Social Welfare, Kumamoto, Japan.
Reika ShinodaSchool of Medicine, Kanazawa Medical University, Ishikawa, Japan.
Hiroshi IshiiDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan.
Mika Takarada-IemataDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan.
Tsuyoshi HattoriDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan.
Seiichi OyadomariDivision of Molecular Biology, Institute for Genome Research, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
Nobuo KatoDepartment of Physiology I, Kanazawa Medical University, Ishikawa, Japan.
Kazutoshi MoriDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.
Osamu HoriDepartment of Neuroanatomy, Graduate School of Medical Sciences, Kanazawa University, 13- 1 Takara-Machi, 920-8640, Kanazawa, Ishikawa, Japan. osamuh3@staff.kanazawa-u.ac.jp.
Kanazawa University · JPKanazawa Medical University · JPHanoi Medical University · VNKumamoto Health Science University · JPKyoto University · JPKyushu University of Nursing and Social Welfare · JPTokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER) stress-regulated transcription factor that induces expression of major molecular chaperones in the ER. We recently reported that ATF6β, a subtype of ATF6, promoted survival of hippocampal neurons exposed to ER stress and excitotoxicity, at least in part by inducing expression of calreticulin, an ER molecular chaperone with high Ca

Indexed as

CalreticulinReceptors, Corticotropin-Releasing HormoneActivating Transcription Factor 6AnimalsAnxietyCorticosteroneCorticotropin-Releasing HormoneHypothalamo-Hypophyseal SystemHypothalamusMicePituitary-Adrenal SystemStress, PsychologicalActivating Transcription Factor 6Atf6b protein, mouseCalreticulinCorticosteroneCorticotropin-Releasing HormoneReceptors, Corticotropin-Releasing HormoneActivating transcription factor 6βAnxiety-like behaviorEndoplasmic reticulum stressHyperactivityHypothalamic-pituitary-adrenal axis

Identifiers

PMID36853481
OpenAlexW4322616793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.