Evidence map›Paper›PMID 36853478›Full record

ArticleAnnals of biomedical engineering2023

The Use of Collagen Methacrylate in Actuating Polyethylene Glycol Diacrylate-Acrylic Acid Scaffolds for Muscle Regeneration.

Yoliem S Miranda Alarcón, Dorota Jazwinska, Terrence Lymon, Amin Khalili, Daniel Browe, Brandon Newton, Michael Pellegrini, Rick I Cohen, David I Shreiber, Joseph W Freeman

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yoliem S Miranda AlarcónDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Dorota JazwinskaDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Terrence LymonDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Amin KhaliliDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Daniel BroweDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Brandon NewtonDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Michael PellegriniDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Rick I CohenDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
David I ShreiberDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA.
Joseph W FreemanDepartment of Biomedical Engineering, Rutgers University, Piscataway, NJ, 08854, USA. joseph.freeman@rutgers.edu.ORCID http://orcid.org/0000-0003-3656-9517
Rutgers, The State University of New Jersey · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After muscle loss or injury, skeletal muscle tissue has the ability to regenerate and return its function. However, large volume defects in skeletal muscle tissue pose a challenge to regenerate due to the absence of regenerative elements such as biophysical and biochemical cues, making the development of new treatments necessary. One potential solution is to utilize electroactive polymers that can change size or shape in response to an external electric field. Poly(ethylene glycol) diacrylate (PEGDA) is one such polymer, which holds great potential as a scaffold for muscle tissue regeneration due to its mechanical properties. In addition, the versatile chemistry of this polymer allows for the conjugation of new functional groups to enhance its electroactive properties and biocompatibility. Herein, we have developed an electroactive copolymer of PEGDA and acrylic acid (AA) in combination with collagen methacrylate (CMA) to promote cell adhesion and proliferation. The electroactive properties of the CMA + PEGDA:AA constructs were investigated through actuation studies. Furthermore, the biological properties of the hydrogel were investigated in a 14-day in vitro study to evaluate myosin light chain (MLC) expression and metabolic activity of C2C12 mouse myoblast cells. The addition of CMA improved some aspects of material bioactivity, such as MLC expression in C2C12 mouse myoblast cells. However, the incorporation of CMA in the PEGDA:AA hydrogels reduced the sample movement when placed under an electric field, possibly due to steric hindrance from the CMA. Further research is needed to optimize the use of CMA in combination with PEGDA:AA as a potential scaffold for skeletal muscle tissue engineering.

Indexed as

CollagenMethacrylatesAcrylatesAnimalsHydrogelsMiceMusclesPolyethylene GlycolsPolymersTissue EngineeringAcrylatesacrylic acidCollagenHydrogelsMethacrylatespoly(ethylene glycol)diacrylatePolyethylene GlycolsPolymersCollagen methacrylamideElectroactive polymersMuscle tissue engineering

Identifiers

PMID36853478
OpenAlexW4322618079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.