Evidence map›Paper›PMID 36853380›Full record

ArticleEuropean journal of nutrition2023

Long-term dietary nitrate supplementation slows the progression of established atherosclerosis in ApoE

Yang Liu, Kevin D Croft, Trevor A Mori, Tracey A Gaspari, Barbara K Kemp-Harper, Natalie C Ward

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yang LiuSchool of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Kevin D CroftSchool of Biomedical Sciences, University of Western Australia, Perth, WA, Australia.
Trevor A MoriMedical School, University of Western Australia, Perth, WA, Australia.
Tracey A GaspariDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Barbara K Kemp-HarperDepartment of Pharmacology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Natalie C WardMedical School, University of Western Australia, Perth, WA, Australia. natalie.ward@uwa.edu.au.ORCID http://orcid.org/0000-0002-6042-437X
The University of Western Australia · AUAustralian Regenerative Medicine Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAtherosclerosis is associated with a reduction in the bioavailability and/or bioactivity of endogenous nitric oxide (NO). Dietary nitrate has been proposed as an alternate source when endogenous NO production is reduced. Our previous study demonstrated a protective effect of dietary nitrate on the development of atherosclerosis in the apoE

methods60 apoE

resultsLong-term supplementation with high dose nitrate resulted in ~ 50% reduction in plaque lesion area. Collagen expression and smooth muscle accumulation were increased, and lipid deposition and macrophage accumulation were reduced within atherosclerotic plaques of mice supplemented with high dose nitrate. These changes were associated with an increase in nitrite reductase as well as activation of the endogenous eNOS-NO pathway.

conclusionLong-term high dose nitrate significantly attenuated the progression of established atherosclerosis in the apoE

Indexed as

AtherosclerosisPlaque, AtheroscleroticAnimalsApolipoproteins EDietary SupplementsDiet, High-FatMiceMice, Inbred C57BLMice, KnockoutNitratesNitric OxideApolipoproteins ENitratesNitric OxideApoE−/− miceAtherosclerosisCardiovascular diseaseNitrate

Identifiers

PMID36853380
PMCPMC10195750
OpenAlexW4322617934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.