Evidence map›Paper›PMID 36853332›Full record

ArticleArchives of toxicology2023

Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor.

Marie H Deventer, Mattias Persson, Antonio Laus, Eline Pottie, Annelies Cannaert, Graziella Tocco, Henrik Gréen, Christophe P Stove

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Marie H DeventerLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0001-6667-2561
Mattias PerssonDepartment of Forensic Genetic and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.ORCID http://orcid.org/0000-0002-4383-2902
Antonio LausDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0002-7227-513X
Eline PottieLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0002-9077-4055
Annelies CannaertLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.ORCID http://orcid.org/0000-0002-8654-1371
Graziella ToccoDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.ORCID http://orcid.org/0000-0003-0081-5704
Henrik GréenDepartment of Forensic Genetic and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden.ORCID http://orcid.org/0000-0002-8015-5728
Christophe P StoveLaboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. christophe.stove@ugent.be.ORCID http://orcid.org/0000-0001-7126-348X
Ghent University · BEUniversity of Cagliari · ITLinköping University · SESwedish National Board of Forensic Medicine · SE

Funding

Eurostars-2 Joint Programme (European Commission (Eurostars-2), NPS-REFORM) E! 113377Fonds Wetenschappelijk Onderzoek 1S54521NStyrkeområdet i forensiska vetenskaper (Strategic Research Area in Forensic Sciences) 2021-10Sweden's Innovation Agency 2019-03566
6 · The paper itself

Abstract

New psychoactive substances (NPS) are introduced on the illicit drug market at a rapid pace. Their molecular targets are often inadequately elucidated, which contributes to the delayed characterization of their pharmacological effects. Inspired by earlier findings, this study set out to investigate the µ opioid receptor (MOR) activation potential of a large set of psychedelics, substances which typically activate the serotonin (5-HT

Indexed as

HallucinogensAnalgesics, OpioidDimethoxyphenylethylamineMolecular Docking SimulationSerotonin2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamineAnalgesics, OpioidDimethoxyphenylethylamineHallucinogensSerotoninBioassayMolecular dockingNBOMeOff-targetPsychedelicsµ opioid receptor

Identifiers

PMID36853332
OpenAlexW4322616471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.