Evidence map›Paper›PMID 36853318›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2023

Role of Cryptosporidium spp in Development of Colorectal Cancer.

Naglaa Fathi Abd El-Latif, Noha Said Kandil, Mohamed Shamseya, Yasmine Nagy Elwany, Heba Said Ibrahim

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06379035 (Blastocystis and Cryptosporidium Infection in Colorectal Cancer Patients), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06379035 unknown statusnot on this mapstarted 2024, after this paper: background citation

Blastocystis and Cryptosporidium Infection in Colorectal Cancer Patients

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled54ConditionsBlastocystis Infection, Cryptosporidium Infection, Colorectal CancerArmsELISA / PCR
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Deciphering Host-Pathogen Interactions: Role ofPathogens (Basel, Switzerland) · 2025
    Review
  6. Current research in parasitology & vector-borne diseases · 2025
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Naglaa Fathi Abd El-LatifDepartment of Parasitology, Medical Research Institute, Alexandria University, Egypt.
Noha Said KandilDepartment of Chemical Pathology, Medical Research Institute, Alexandria University, Egypt.
Mohamed ShamseyaDepartment of Internal Medicine, Medical Research Institute, Alexandria University, Egypt.
Yasmine Nagy ElwanyDepartment of Cancer Management and Research, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Heba Said IbrahimDepartment of Parasitology, Medical Research Institute, Alexandria University, Egypt.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer is one of the most common malignancies in humans. About 20% of the cancer incidence was attributed to infectious agents highlighting the association between infectious agents and the development of cancers. It has been suspected that Cryptosporidium spp. infection may be correlated with colon adenocarcinoma.  Aim: investigate the percentage of cryptosporidiosis among colorectal cancer patients. SUBJECTS: 100 patients were recruited from Medical Research Institute, Alexandria University.

methodsFresh stool specimens were collected, homogenized and examined using direct wet mount and by permanent staining of faecal smears using Modified ZN staining. Molecular detection by PCR amplification of Cryptosporidium COWP gene.

resultsSignificantly higher proportion of colorectal cancer patients (32.5%, 42.5%) tested positive by MZN and ELISA respectively compared to only 3.3% and 5% of positive MZN and ELISA among control group. Also, positive PCR was detected among higher proportion of colorectal cancer patients (47.5%) and only 5% of control group. Odds of colorectal cancer is 19 times among positive cases of Cryptosporidium by PCR than those without proven infection by PCR (OR 19.12; 95% CI 4.82-75.99). Comparison of the assessment of Cryptosporidium infection made by two techniques produces a kappa value of 0.770, and .759 respectively between NZN, ELISA and PCR as a gold standard, suggesting a good agreement between the two techniques and PCR. This value of kappa is significantly different from zero, K.770, p<0.001 for MZN and K.759, p<.001 for ELISA. Specificity of MZN (100%) is higher than that of ELISA (96.2%) and both reported higher specificity than sensitivity denoting that both tests are good positive to rule in the presence of infection at 40% prevalence.

conclusionCryptosporidium infection is significantly higher among cancer colon patients reinforcing that it might be considered as a likely risk factor for the development cancer colon.

Indexed as

AdenocarcinomaColonic NeoplasmsCryptosporidiosisCryptosporidiumHumansPolymerase Chain ReactionCancer colonCryptosporidiumElisa and PCRZN modified staining

Identifiers

PMID36853318
PMCPMC10162599
OpenAlexW4322618036

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.