ArticleAsian Pacific journal of cancer prevention : APJCP2023
Predictive Factors for Post-Hepatectomy Liver Failure in Patients with Cholangiocarcinoma.
Article in Asian Pacific journal of cancer prevention : APJCP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Economic Evaluation and Budget Impact Analysis of Indocyanine Green Test for Preoperative Liver Function in Patients with Major Hepatectomy in Thailand.Advances in therapy · 2025Article
- A comparative study of machine learning models predicting post-hepatectomy liver failure: Enhancing risk estimation in over 25,000 National Surgical Quality Improvement Program patients.Annals of hepato-biliary-pancreatic surgery · 2025Article
- A New Prognostic Indicator for Biliary Tract Cancers: The ABIC Score.Current oncology (Toronto, Ont.) · 2025Article
- Clinical significances of liver fibrotic markers in patients with cholangiocarcinoma after radical resections.Turkish journal of surgery · 2024Article
- Predictive Value of Preoperative ICG-R15 Testing in Post-hepatectomy Liver Failure Following Major Liver Resection: Indian Experience.Indian journal of surgical oncology · 2024Article
- Complete regression of intrahepatic cholangiocarcinoma after right portal vein ligation. Case report.International journal of surgery case reports · 2024Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundCholangiocarcinoma (CCA) is a cancer of biliary tract with a different incidence across the globe. The northeast part of Thailand has the highest incidence of CCA. Post-hepatectomy liver failure (PHLF) is the most severe and life-threatening complication in CCA patients. The aim of this study was to identify factors related to PHLF incidence in patients with CCA.
methodsAn analytical cross-sectional study was performed in a university hospital in northeast Thailand between January 1, 2014 and December 31, 2020. PHLF grading criteria was used according to the international study group of liver surgery definition for PHLF. Multiple Logistic Regression with a stepwise forward method was employed to identify the predictive factors related to PHLF.
resultThe study findings revealed that 185 patients developed PHLF, of whom 56.22% experience grade A, 36.76% grade B, and 7.06% grade C PHLF. Based on our findings, seventeen factors were significantly correlated with PHLF incidence, namely age, cholangiocarcinoma type, hepatectomy type, preoperative biliary drainage, cholangitis, Child-Turcotte-Pugh grade, operation time, total blood loss, total blood transfusion, level of serum albumin, total bilirubin, direct bilirubin, alanine transaminase, aspartate transaminase, alkaline phosphatase, prothrombin time, and level of international normalized ratio. Total bilirubin (adjusted OR=14.07, 95% CI 7.54-26.27), Child-Turcotte-Pugh grade (adjusted OR=3.34, 95% CI 1.43-7.81), total blood transfusion (adjusted OR=2.32, 95% CI 1.19-4.54), and operation time (adjusted OR=1.77, 95% CI 1.05-2.97) could significantly predict PHLF incidence with a positive predictive value of 86.03% and a negative predictive value of 80.23%, while the accuracy of prediction was 81.88%.
conclusionThe findings of this study identified total bilirubin, Child-Turcotte-Pugh grade, total blood transfusion, and operation time as clinical predictive factors of PHLF. Therefore, modification of these factors is recommended to reduce the probability of liver failure in CCA patients.
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