Evidence map›Paper›PMID 36853030›Full record

ArticleAntimicrobial agents and chemotherapy2023

Local Regulator AcrR Regulates Persister Formation by Repression of AcrAB Efflux Pump during Exponential Growth in Aeromonas veronii.

Xiang Ma, Kang Hu, Yuesheng Xiong, Hong Li, Juanjuan Li, Yanqiong Tang, Zhu Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Bacterial persisters: molecular mechanisms and therapeutic development.Signal transduction and targeted therapy · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiang Ma *School of Life Sciences, Hainan University, Haikou, China.ORCID 0000-0003-0103-861X
Kang Hu *School of Life Sciences, Hainan University, Haikou, China.
Yuesheng Xiong *School of Life Sciences, Hainan University, Haikou, China.
Hong LiSchool of Life Sciences, Hainan University, Haikou, China.
Juanjuan LiSchool of Life Sciences, Hainan University, Haikou, China.
Yanqiong TangSchool of Life Sciences, Hainan University, Haikou, China.
Zhu LiuSchool of Life Sciences, Hainan University, Haikou, China.
Hainan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial persisters refer to a small fraction of dormant variants that survive treatment with high concentrations of antibiotics. Increasing research indicates that multidrug efflux pumps play a major role in persister formation in many Gram-negative organisms. In the present study, the roles of the repressor of the AcrAB efflux pump, AcrR, in the regulation of the activity and function of the efflux, as well as in the production of persisters, were investigated in the pathogen Aeromonas veronii, which causes huge economic losses in the aquatic industry and threatens human health. We observed that exclusively in exponential-phase cells, not in stationary-phase cells, the deletion of the

Indexed as

Aeromonas veroniiEscherichia coli ProteinsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsChloramphenicolHumansTetracyclinesAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsChloramphenicolEscherichia coli ProteinsTetracyclinesAcrABAcrRAeromonas veroniibacterial efflux pumppersister formation

Identifiers

PMID36853030
PMCPMC10019292
OpenAlexW4322616936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.