Evidence map›Paper›PMID 36853029›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2023

At the Crossroad of Nucleotide Dynamics and Protein Synthesis in Bacteria.

Lorenzo Eugenio Leiva, Victor Zegarra, Gert Bange, Michael Ibba

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lorenzo Eugenio Leiva *Schmid College of Science and Technology, Chapman University, Orange, California, USA.
Victor Zegarra *Center for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Gert BangeCenter for Synthetic Microbiology, Philipps-University Marburg, Marburg, Germany.
Michael IbbaSchmid College of Science and Technology, Chapman University, Orange, California, USA.ORCID 0000-0002-5318-1605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleotides are at the heart of the most essential biological processes in the cell, be it as key protagonists in the dogma of molecular biology or by regulating multiple metabolic pathways. The dynamic nature of nucleotides, the cross talk between them, and their constant feedback to and from the cell's metabolic state position them as a hallmark of adaption toward environmental and growth challenges. It has become increasingly clear how the activity of RNA polymerase, the synthesis and maintenance of tRNAs, mRNA translation at all stages, and the biogenesis and assembly of ribosomes are fine-tuned by the pools of intracellular nucleotides. With all aspects composing protein synthesis involved, the ribosome emerges as the molecular hub in which many of these nucleotides encounter each other and regulate the state of the cell. In this review, we aim to highlight intracellular nucleotides in bacteria as dynamic characters permanently cross talking with each other and ultimately regulating protein synthesis at various stages in which the ribosome is mainly the principal character.

Indexed as

NucleotidesProtein BiosynthesisBacteriaRibosomesNucleotidesnucleotidesprotein synthesisribosomeRNAtranslation

Identifiers

PMID36853029
PMCPMC10029340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.