Evidence map›Paper›PMID 36853012›Full record

ArticleAntimicrobial agents and chemotherapy2023

Therapeutic, Humanized Monoclonal Antibody Exhibits Broad Binding and Protective Efficacy against Acinetobacter baumannii.

Matthew Slarve, Zeferino Reyna, Elizabeth Burk, Juan Ruiz-Delgado, Rachel Li, Jun Yan, Brian Luna, Brad Spellberg

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  3. Review
  4. Article
  5. Antivirulence drugs against Acinetobacter baumannii: where do they stand?World journal of microbiology & biotechnology · 2025
    Review
  6. Monoclonal Antibody Therapies for Infectious Diseases.Current topics in microbiology and immunology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthew SlarveDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Zeferino ReynaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Elizabeth BurkDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Juan Ruiz-DelgadoDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Rachel LiDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Jun YanDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.
Brian LunaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine of USC, Los Angeles, California, USA.ORCID 0000-0001-6718-4551
Brad SpellbergLos Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA.
Keck Hospital of USC · USLAC+USC Medical Center · US

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
Characterization of Rifabutin Therapy Against Antibiotic-Resistant BacteriaR01AI139052 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUNA, BRIAN MICHAEL · 2018 to 2021
$2.4M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 2R01AI130060HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139052NIAID NIH HHS R01 AI130060
6 · The paper itself

Abstract

Acinetobacter baumannii is an extremely drug-resistant pathogen necessitating the development of new therapies. We seek to generate a cocktail of monoclonal antibodies (MAbs) that can target the full diversity of A. baumannii isolates. We have newly identified the antibody MAb5. Here, we demonstrate that MAb5 has broad binding against U.S. (

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansO AntigensAnti-Bacterial AgentsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedO AntigensAcinetobacter baumanniiantibiotic resistancecarbohydratesK antigenmonoclonal antibodyO antigentherapeutic

Identifiers

PMID36853012
PMCPMC10019318
OpenAlexW4322617723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.