Evidence map›Paper›PMID 36852908›Full record

ArticleJournal of cardiovascular electrophysiology2023

Ambient circulation surrounding an ablation catheter tip affects ablation lesion characteristics.

Udi Nussinovitch, Paul Wang, Meghedi Babakhanian, Sanjiv M Narayan, Mohan Viswanathan, Nitish Badhwar, Lijun Zheng, William H Sauer, Duy T Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Udi NussinovitchSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Paul WangSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Meghedi BabakhanianSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Sanjiv M NarayanSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Mohan ViswanathanSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Nitish BadhwarSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.
Lijun ZhengSection of Cardiac Electrophysiology, Division of Cardiology, University of Colorado, Aurora, Colorado, USA.
William H SauerSection of Cardiac Electrophysiology, Division of Cardiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-7070-0307
Duy T NguyenSection of Cardiac Electrophysiology, Division of Cardiovascular Medicine, Stanford University, Stanford, California, USA.ORCID 0000-0001-6570-6010

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
Machine Learning in Atrial FibrillationR01HL149134 · NHLBI · STANFORD UNIVERSITY · PI NARAYAN, SANJIV M · 2020 to 2024
$3.8M
Machine Learning for Ventricular ArrhythmiasR01HL162260 · NHLBI · STANFORD UNIVERSITY · PI Sanjiv M Narayan · 2023 to 2026
$2.5M
NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL149134NHLBI NIH HHS R01 HL162260
6 · The paper itself

Abstract

introductionThe association between ambient circulating environments (CEs) and ablation lesions has been largely underexplored.

methodsViable bovine myocardium was placed in a saline bath in an ex vivo endocardial model. Radiofrequency (RF) ablation was performed using three different ablation catheters: 3.5 mm open irrigated (OI), 4, and 8 mm. Variable flow rates of surrounding bath fluids were applied to simulate standard flow, high flow, and no flow. For in vivo epicardial ablation, 24 rats underwent a single OI ablation and performed with circulating saline (30 ml/min; n = 12), versus those immersed in saline without circulation (n = 12).

resultsHigh flow reduced ablation lesion volumes for all three catheters. In no-flow endocardial CE, both 4 mm and OI catheters produced smaller lesions compared with standard flow. However, the 8 mm catheter produced the largest lesions in a no-flow CE. Ablation performed in an in vivo model with CE resulted in smaller lesions compared with ablation performed in a no-flow environment. No statistically significant differences in steam pops were found among the groups.

conclusionA higher endocardial CE flow can decrease RF effectiveness. Cardiac tissue subjected to no endocardial CE flow may also limit RF for 4 mm catheters, but not for OI catheters; these findings may have implications for RF ablation safety and efficacy, especially in the epicardial space without circulating fluid or in the endocardium under varying flow conditions.

Indexed as

HeartMyocardiumAnimalsCathetersCattleEndocardiumEquipment DesignRatscatheter ablationcirculating environmentlesion volumeradiofrequency

Identifiers

PMID36852908
PMCPMC10115146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.