ArticlePlant physiology2023
Repressive ZINC FINGER OF ARABIDOPSIS THALIANA proteins promote programmed cell death in the Arabidopsis columella root cap.
Article in Plant physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
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- The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors.Biology · 2026Review
- FANS uncovers WOX2-associated early regulators of auxin-induced somatic embryogenesis in Arabidopsis.BMC plant biology · 2026Article
- GhZAT11 triggers wound-activated bud growth by accelerating sugar transport and cell division.Nature plants · 2026Article
- Functional characterization of four soybean C2H2 zinc-finger genes inPlant signaling & behavior · 2025Article
- The ZAT14 family promotes cell death and regulates expansins to affect xylem formation and salt tolerance in Arabidopsis.The Plant cell · 2025Article
- Gatekeeping symbiosis: autophagy shapes Serendipita indica -Arabidopsis thaliana interaction.Plant physiology · 2025Article
- The molecular framework balancing growth and defense in response to plant elicitor peptide-induced signals in Arabidopsis.The Plant cell · 2024Article
- Comprehensive Transcriptome and Proteome Analyses Reveal the Drought Responsive Gene Network in Potato Roots.Plants (Basel, Switzerland) · 2024Article
- Comparative transcriptomics analysis reveals defense mechanisms of Manihot esculenta Crantz against Sri Lanka Cassava MosaicVirus.BMC genomics · 2024Article
- Transcriptomic and co-expression network analyses on diverse wheat landraces identifies candidate master regulators of the response to early drought.Frontiers in plant science · 2023Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Developmental programmed cell death (dPCD) controls a plethora of functions in plant growth and reproduction. In the root cap of Arabidopsis (Arabidopsis thaliana), dPCD functions to control organ size in balance with the continuous stem cell activity in the root meristem. Key regulators of root cap dPCD including SOMBRERO/ANAC033 (SMB) belong to the NAC family of transcription factors. Here, we identify the C2H2 zinc finger protein ZINC FINGER OF ARABIDOPSIS THALIANA 14 ZAT14 as part of the gene regulatory network of root cap dPCD acting downstream of SMB. Similar to SMB, ZAT14-inducible misexpression leads to extensive ectopic cell death. Both the canonical EAR motif and a conserved L-box motif of ZAT14 act as transcriptional repression motifs and are required to trigger cell death. While a single zat14 mutant does not show a cell death-related phenotype, a quintuple mutant knocking out 5 related ZAT paralogs shows a delayed onset of dPCD execution in the columella and the adjacent lateral root cap. While ZAT14 is co-expressed with established dPCD-associated genes, it does not activate their expression. Our results suggest that ZAT14 acts as a transcriptional repressor controlling a so far uncharacterized subsection of the dPCD gene regulatory network active in specific root cap tissues.
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