Evidence map›Paper›PMID 36852503›Full record

ReviewInterventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences2026

The impact of funding on the quality and interpretation of systematic reviews of mechanical thrombectomy in stroke patients.

Sherief Ghozy, Amr Ehab El-Qushayri, Mohamed Ibrahim Gbreel, Ramadan Abdelmoez Farahat, Ahmed Y Azzam, Mohamed Elfil, Hassan Kobeissi, Adam Dmytriw, Fawaz Al-Mufti, Ramanathan Kadirvel and 1 more

Abstract readReview
In one paragraph

Review in Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sherief GhozyDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5629-3023
Amr Ehab El-QushayriNested Knowledge, St Paul, MN, USA.ORCID 0000-0002-0967-797X
Mohamed Ibrahim GbreelNested Knowledge, St Paul, MN, USA.
Ramadan Abdelmoez FarahatNested Knowledge, St Paul, MN, USA.
Ahmed Y AzzamNested Knowledge, St Paul, MN, USA.
Mohamed ElfilDepartment of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-1125-2946
Hassan KobeissiDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7446-624X
Adam DmytriwNeurointerventional Program, Departments of Medical Imaging and Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.ORCID 0000-0003-0131-5699
Fawaz Al-MuftiDepartment of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.ORCID 0000-0003-4461-7005
Ramanathan KadirvelDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-6786-9953
David F KallmesDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8495-0040

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundFunding may impact the quality and findings of systematic reviews (SRs). We aimed to compare the methodological quality of funded and non-funded SRs that investigated the outcomes in ischemic stroke patients undergoing mechanical thrombectomy.MethodsWe conducted a comprehensive search strategy in different databases, including Ovid Cochrane Central Register of Controlled Trials, Ovid Embase, Ovid Medline (including epub ahead of print, in-process & other non-indexed citations), PubMed, Scopus and Web of Science Core Collection to retrieve all relevant SRs. Random sequence generation matched each funded SR with a non-funded one. A Measurement Tool to Assess Systematic Reviews (AMSTAR)-2 tool was used to assess the bias and quality of the included SRs. We also used uni- and multivariate analysis to perform our analysis, and results were expressed in odds ratio (OR) and 95% confidence interval (CI).ResultsWe retrieved 150 articles, which were randomized and matched into 100 SRs, including 50 funded and 50 non-funded studies. By multivariate analysis, we found that including randomized clinical trials (RCTs) (OR: 5.7; 95% CI: 1.8-17.8; p = 0.003) and reporting conflict of interests (OR: 5.2; 95 CI: 1.1-24; p = 0.036) were the only significant differences between funded and non-funded SRs. No significant differences were found regarding the overall confidence for low-quality (OR: 0.54; 95% CI: 0.09-3.2; p = 0.49) and moderate/high-quality SRs (OR: 0.17; 95% CI: 0.02-1.87; p = 0.14).ConclusionFunded studies tend to include RCTs more often and report conflict of interests with no significant impact on overall confidence.

Indexed as

StrokeThrombectomyHumansReview Literature as TopicSystematic Reviews as Topicfundingstrokesystematic reviewthrombectomy

Identifiers

PMID36852503
PMCPMC13294527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.