Evidence map›Paper›PMID 36852397›Full record

ArticleRegenerative biomaterials2023

Selenium-modified bone cement promotes osteoporotic bone defect repair in ovariectomized rats by restoring GPx1-mediated mitochondrial antioxidant functions.

Quan Zhou, Weikai Chen, Chao Gu, Hao Liu, Xiayu Hu, Lei Deng, Wei He, Yong Xu, Xuesong Zhu, Huilin Yang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
  2. Tri-Functional MgTA@MnOInternational journal of nanomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Quan ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Weikai ChenDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Chao GuOrthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China.
Hao LiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Xiayu HuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Lei DengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Wei HeDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yong XuOrthopaedic Institute, Medical College, Soochow University, Suzhou 215007, China.
Xuesong ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Xi ChenDepartment of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
Fan HeDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.ORCID https://orcid.org/0000-0001-5357-1374
Tao LiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over-accumulation of reactive oxygen species (ROS) causes mitochondrial dysfunction and impairs the osteogenic potential of bone marrow-derived mesenchymal stem cells (BMMSCs). Selenium (Se) protects BMMSCs from oxidative stress-induced damage; however, it is unknown whether Se supplementation can promote the repair of osteoporotic bone defects by rescuing the impaired osteogenic potential of osteoporotic BMMSCs (OP-BMMSCs).

Indexed as

bone cementGPx1mitochondrial functionosteoporosissodium selenite

Identifiers

PMID36852397
PMCPMC9960915
OpenAlexW4320726076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.