Evidence map›Paper›PMID 36852396›Full record

ArticleMediators of inflammation2023

Induced Inflammatory and Oxidative Markers in Cerebral Microvasculature by Mentally Depressive Stress.

Yuequan Zhu, Yazeed Haddad, Ho Jun Yun, Xiaokun Geng, Yuchuan Ding

Abstract read
In one paragraph

Article in Mediators of inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuequan ZhuChina-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, China.ORCID https://orcid.org/0000-0003-4775-7601
Yazeed HaddadDepartment of Neurosurgery, Wayne State University School of Medicine, USA.
Ho Jun YunDepartment of Neurosurgery, Wayne State University School of Medicine, USA.
Xiaokun GengChina-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, China.ORCID https://orcid.org/0000-0001-8918-8748
Yuchuan DingDepartment of Neurosurgery, Wayne State University School of Medicine, USA.ORCID https://orcid.org/0000-0001-5358-1660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cerebrovascular disease (CVD) is recognized as the leading cause of permanent disability worldwide. Depressive disorders are associated with increased incidence of CVD. The goal of this study was to establish a chronic restraint stress (CRS) model for mice and examine the effect of stress on cerebrovascular inflammation and oxidative stress responses. Methods: A total of forty 6-week-old male C57BL/6J mice were randomly divided into the CRS and control groups. In the CRS group ( Results: CRS decreased the total distances ( Conclusions: To our knowledge, this is the first study to demonstrate that CRS induces depressive stress and causes inflammatory and oxidative stress responses in the brain microvasculature.

Indexed as

Cardiovascular DiseasesHydrogen PeroxideAnimalsDepressive DisorderInterleukin-6MaleMiceMice, Inbred C57BLMicrovesselsReactive Oxygen SpeciesTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Hydrogen PeroxideInterleukin-6Reactive Oxygen SpeciesTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1

Identifiers

PMID36852396
PMCPMC9966573

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.