Evidence map›Paper›PMID 36852281›Full record

ArticleiScience2023

High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells.

Weifeng Li, Cynthia Berlinicke, Yinyin Huang, Stefanie Giera, Anna G McGrath, Weixiang Fang, Chaoran Chen, Felipe Takaesu, Xiaoli Chang, Yukan Duan and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Weifeng LiDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Cynthia BerlinickeDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yinyin HuangSanofi Inc., Translational Science, 350 Water Street, Cambridge, MA, 02141, USA.
Stefanie GieraSanofi Inc., Rare and Neurologic Diseases Therapeutic Area, 350 Water Street, Cambridge, MA, 02141, USA.
Anna G McGrathSanofi Inc., Rare and Neurologic Diseases Therapeutic Area, 350 Water Street, Cambridge, MA, 02141, USA.
Weixiang FangDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Chaoran ChenDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Felipe TakaesuWallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine & Georgia Institute of Technology, Atlanta, GA, USA.
Xiaoli ChangDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yukan DuanDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Dinesh KumarSanofi Inc., Translational Science, 350 Water Street, Cambridge, MA, 02141, USA.
Calvin ChangDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Hai-Quan MaoDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
Guoqing ShengSanofi Inc., Rare and Neurologic Diseases Therapeutic Area, 350 Water Street, Cambridge, MA, 02141, USA.
James C DodgeSanofi Inc., Rare and Neurologic Diseases Therapeutic Area, 350 Water Street, Cambridge, MA, 02141, USA.
Hongkai JiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Stephen MaddenSanofi Inc., Translational Science, 350 Water Street, Cambridge, MA, 02141, USA.
Donald J ZackDepartment of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Xitiz ChamlingDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Johns Hopkins University · USSanofi (United States) · USGeorgia Institute of Technology · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Jiang Qian · 1985 to 2026
$22.1M
Developing Remyelination Strategies for Demyelinating Optic Neuropathies Using Human Pluripotent Stem CellsR00EY029011 · NEI · JOHNS HOPKINS UNIVERSITY · PI CHAMLING, XITIZ · 2022 to 2024
$731k
Promote Organization and Integration of Regenerated Neurons from Transplanted Human Neural Stem CellsR21NS096668 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2017 to 2018
$450k
Developing Remyelination Strategies for Demyelinating Optic Neuropathies Using Human Pluripotent Stem CellsK99EY029011 · NEI · JOHNS HOPKINS UNIVERSITY · PI CHAMLING, XITIZ · 2019 to 2021
$294k
NEI NIH HHS K99 EY029011NEI NIH HHS P30 EY001765NEI NIH HHS R00 EY029011NINDS NIH HHS R21 NS096668
6 · The paper itself

Abstract

Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for CNS demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination-promoting compounds, we generated a genome-engineered human pluripotent stem cell (hPSC) line that consists of three reporters: identification-and-purification tag, GFP, and secreted-NanoLuc, driven by the endogenous

Indexed as

Cell biologyNeuroscienceStem cells research

Identifiers

PMID36852281
PMCPMC9958491
OpenAlexW4319601372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.