ReviewJournal of Taibah University Medical Sciences2023
Protein-based salivary biomarkers for the diagnosis of periodontal diseases: Systematic review and meta-analysis.
Review in Journal of Taibah University Medical Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Periodontal Indices and Cytokines of Ex-Smokers/Non-Smokers After Bleaching.Medicina (Kaunas, Lithuania) · 2026Article
- Changes in Salivary Interleukin-1 Beta Levels Following a Care Worker-Centered Oral Health Care Program Among Residents of Long-Term Care Facilities.Healthcare (Basel, Switzerland) · 2026Article
- Association of salivary proteins with periodontal disease in children and adolescents- a scoping review.BMC oral health · 2026Article
- The role of salivary lactoferrin as a potential biomarker for periodontal disease: a systematic review and meta-analysis.Frontiers in oral health · 2026Review
- High Salivary 3-Nitrotyrosine Levels in Periodontitis.Journal of clinical medicine · 2025Article
- The Evolving Landscape of Host Biomarkers for Diagnosis and Monitoring of Tuberculosis.Biomedicines · 2025Review
- Elevated levels of salivary interleukin-34 in patients suffering from Alzheimer's disease.Clinical oral investigations · 2025Article
- High Salivary Malondialdehyde Levels Are Associated with Periodontitis Independently of Other Risk Factors.Journal of clinical medicine · 2025Article
- Alveolar bone loss is associated with oral cancer: a case-control study.Frontiers in oral health · 2025Article
- Are Salivary and Plasma Levels of Toll-Like Receptors 2 and 4 Elevated in Subjects With Chronic Periodontitis?: A Systematic Review and Meta-Analysis.International journal of inflammation · 2025Review
- A Roadmap for the Rational Use of Biomarkers in Oral Disease Screening.Biomolecules · 2024Review
- Beneficial effects of non-invasive physical plasma on human periodontal ligament cellsFrontiers in medicine · 2024Article
- Diagnostic Potential of Salivary Interleukin-1International journal of dentistry · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis was aimed at determining differentially expressed protein-based biomarkers detectable in the saliva for the diagnosis of major periodontal diseases. Methods: A literature review was conducted through January 31, 2022. The methodological quality and risk of bias were assessed with the Newcastle-Ottawa scale for case-control studies. Heterogeneity among studies was analysed with the Q statistical test and the I Results: Of all protein-based biomarkers detected, 12 were suitable for meta-analysis: IL-1β, MIP-1α, albumin, TNF-α, ICTP, Ig-A, lactoferrin, MMP-8, IL-6, IL-8, IL-17 and PGE2. The salivary markers with high applicability were IL-1β for differentiating patients with chronic periodontal disease from patients with gingivitis with an OE = 73.5 pg/mL; ICTP for differentiating patients with chronic periodontal disease from healthy control patients with an OE = 0.091 ng/mL; and PGE2 for differentiating patients with chronic periodontal disease from healthy control patients with an OE = 36.3 pg/mL. Conclusions: The biomarkers with the highest differential expression and the greatest potential for clinical applicability are IL-1β for differentiating periodontitis from gingivitis, and ICTP and PGE2 for differentiating periodontitis from healthy status.
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