Evidence map›Paper›PMID 36852171›Full record

ArticleJVS-vascular science2023

Cystathionine-γ-lyase overexpression modulates oxidized nicotinamide adenine dinucleotide biosynthesis and enhances neovascularization.

Kevin Kiesworo, Michael R MacArthur, Peter Kip, Thomas Agius, Diane Macabrey, Martine Lambelet, Lauriane Hamard, C-Keith Ozaki, James R Mitchell, Sébastien Déglise and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Kevin KiesworoDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Michael R MacArthurDepartment of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Peter KipDepartment of Surgery and Heart and Vascular Center, Brigham & Women's Hospital and Harvard Medical School, Boston, MA.
Thomas AgiusDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Diane MacabreyDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Martine LambeletDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Lauriane HamardDepartment of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
C-Keith OzakiDepartment of Surgery and Heart and Vascular Center, Brigham & Women's Hospital and Harvard Medical School, Boston, MA.
James R MitchellDepartment of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Sébastien DégliseDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Sarah J MitchellDepartment of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Florent AllagnatDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Alban LongchampDepartment of Vascular Surgery, Lausanne University Hospital, Lausanne, Switzerland.
University of Lausanne · CHETH Zurich · CHBrigham and Women's Hospital · US

Funding

Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Dietary methionine restriction as an exercise mimetic via increased muscle oxidative metabolismF31AG064863 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MACARTHUR, MICHAEL · 2019 to 2019
$36k
NIA NIH HHS F31 AG064863NIDDK NIH HHS R01 DK090629
6 · The paper itself

Abstract

Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease. However, the benefits of increasing endogenous CGL and its mechanism of action have not yet been elucidated. Methods: Male whole body CGL-overexpressing transgenic (CGL Results: The restoration of blood flow occurred more rapidly in CGL Conclusions: Our results have demonstrated that CGL overexpression improves the neovascularization of skeletal muscle on hindlimb ischemia. These effects correlated with changes in the NAD pathway, which improved EC migration.

Indexed as

CGLEndothelial cellsHydrogen sulfidePeripheral arterial disease

Identifiers

PMID36852171
PMCPMC9958478
OpenAlexW4315864678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.