Evidence map›Paper›PMID 36851996›Full record

ArticleCerebral circulation - cognition and behavior2023

Impaired oxygen extraction and adaptation of intracellular energy metabolism in cerebral small vessel disease.

Annemarie Reiländer, Ulrich Pilatus, Jan-Rüdiger Schüre, Manoj Shrestha, Ralf Deichmann, Ulrike Nöth, Elke Hattingen, René-Maxime Gracien, Marlies Wagner, Alexander Seiler

Open access · goldAbstract read
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Annemarie ReiländerDepartment of Neurology, Goethe University Hospital Frankfurt, Schleusenweg 2-16, Frankfurt 60528, Germany.
Ulrich PilatusInstitute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
Jan-Rüdiger SchüreInstitute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
Manoj ShresthaBrain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Ralf DeichmannBrain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Ulrike NöthBrain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Elke HattingenInstitute of Neuroradiology, Goethe University Hospital Frankfurt, Frankfurt Germany.
René-Maxime GracienDepartment of Neurology, Goethe University Hospital Frankfurt, Schleusenweg 2-16, Frankfurt 60528, Germany.
Marlies WagnerBrain Imaging Center, Goethe University Hospital Frankfurt, Frankfurt Germany.
Alexander SeilerDepartment of Neurology, Goethe University Hospital Frankfurt, Schleusenweg 2-16, Frankfurt 60528, Germany.
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to investigate whether combined phosphorous ( Materials and methods: 32 patients with SVD and 17 age-matched healthy control subjects were examined with 3-dimensional Results: Quantitative Conclusions: This exploratory study found evidence of impaired cerebral OEF in SVD, which is associated with intracellular alkalosis as an adaptive mechanism. The employed techniques provide new insights into the pathophysiology of SVD with regard to disease-related consequences on the cellular metabolic state.

Indexed as

BBB, blood-brain barrierCBF, cerebral blood flowCBV, cerebral blood volumeCellular energy metabolismCMRO2, Cerebral metabolic rate of oxygenDTI, diffusion tensor imagingGE, gradient echoHb, hemoglobinICA, internal carotid arteryMicrostructural impairmentMRI, magnetic resonance imagingMRSI, magnetic resonance spectroscopic imagingMRS, magnetic resonance spectroscopyMR spectroscopyNAWM, normal-appearing white matterOEF, oxygen extraction fractionOxygen extraction fractionpHi, intracellular pHPI, Pulsatility indexquantitative MRIRF, radio frequencySmall vessel diseaseSVD, cerebral small vessel diseaseTR, repetition timeWMH, white matter hyperintensitiesWM, white matter

Identifiers

PMID36851996
PMCPMC9957754
OpenAlexW4319940549

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.