ArticleThe Lancet regional health. Western Pacific2023
Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study.
Article in The Lancet regional health. Western Pacific, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Association between abdominal obesity and cognitive outcomes in middle-aged adults: a systematic review.Frontiers in nutrition · 2026Pooled it
- The Development and Validation of the Food Memory Bias Test for a Large-Scale Epidemiological Study in a Multiethnic Asian Population.Nutrients · 2026Article
- Longitudinal association between visceral adiposity index and arthritis-diabetes comorbidity risk: A cohort study from CHARLS.Medicine · 2026Article
- Discordance between remnant cholesterol and low-density lipoprotein cholesterol predicts incident hypertension: a 9-year prospective cohort study in Chinese adults.BMC cardiovascular disorders · 2026Article
- Article
- Impact of body roundness index on cognitive decline and cognitive impairment in middle-aged and older adults ≥ 45 years: mediating role of biological aging.Scientific reports · 2026Article
- Weight-adjusted waist index and cognitive impairment in older adults: A nationwide longitudinal cohort study.Medicine · 2026Article
- Obesity-Related Cognitive Impairment: An Update Overview of Mechanisms and Treatments.Expert reviews in molecular medicine · 2026Review
- Article
- Association between visceral adiposity index and incident dementia: a community-based cohort study.BMC psychiatry · 2026Article
- Association Between Relative Fat Mass and Risk of Cognitive Impairment: The Role of Social Determinants of Health.Actas espanolas de psiquiatria · 2026Article
- Dietary patterns in Xinjiang, Western China and associations with metabolic syndrome: a population-based study.Public health nutrition · 2026Article
- Sex-Specific Biological Aging-Related Lipidomic Profiles Mediate the Impact of Urinary Polycyclic Aromatic Hydrocarbon Exposures on Cognitive Function in Healthy Older Adults.Environment & health (Washington, D.C.) · 2026Article
- Visceral fat metabolism score and cardiovascular-kidney-metabolic syndrome stages in all-cause and cause-specific mortality: insights from UK Biobank.Nutrition & metabolism · 2026Article
- Systematic analysis of associations between obesity and memory decline.GeroScience · 2026Article
- Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China.Frontiers in aging neuroscience · 2026Article
- Adipose tissue distribution in metabolic disease: depot-specific biology, clinical assessment, and therapeutic remodeling.Frontiers in endocrinology · 2026Review
- Associations of novel visceral obesity indices (METS-VF and BRI) with dementia: the role of metabolic mediators and genetic susceptibility.Frontiers in nutrition · 2026Article
- Association between waist-to-height ratio and cognitive impairment among community-dwelling elderly adults in Laoshan, Qingdao: a cross-sectional study.Frontiers in nutrition · 2026Article
- Novel anthropometric indices and cognitive function among iranian older adults: Bushehr Elderly Health (BEH) program.PloS one · 2026Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obesity and related metabolic disturbances including diabetes, hypertension and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both obesity and metabolic disease, potentially amplifying the future burden of dementia in the region. We aimed to investigate the impact of adiposity and metabolic risk on cognitive function in Asian populations, using an epidemiological analysis and a two-sample Mendelian Randomization (MR) study. Methods: The Health for Life in Singapore (HELIOS) Study is a population-based cohort of South-East-Asian men and women in Singapore, aged 30-84 years. We analyzed 8769 participants with metabolic and cognitive data collected between 2018 and 2021. Whole-body fat mass was quantified with Dual X-Ray Absorptiometry (DEXA). Cognition was assessed using a computerized cognitive battery. An index of general cognition ' Findings: Participants were 58.9% female, and aged 51.4 (11.3) years. In univariate analysis, all 29 adiposity and metabolic measures assessed were associated with ' Interpretation: We show an independent relationship between adiposity and cognition in a multi-ethnic Asian population. MR analyses suggest that both visceral adiposity and raised BMI are likely to be causally linked to cognition. Our findings have important implications for preservation of cognitive health, including further motivation for action to reverse the rising burden of obesity in the Asia-Pacific region. Funding: The Nanyang Technological University-the Lee Kong Chian School of Medicine, National Healthcare Group, National Medical Research Council, Ministry of Education, Singapore.
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