Evidence map›Paper›PMID 36851793›Full record

ArticleViruses2023

High Prevalence of Alternative Diagnoses in Children and Adolescents with Suspected Long COVID-A Single Center Cohort Study.

Sarah C Goretzki, Maire Brasseler, Burcin Dogan, Tom Hühne, Daniel Bernard, Anne Schönecker, Mathis Steindor, Andrea Gangfuß, Adela Della Marina, Ursula Felderhoff-Müser and 2 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Sarah C GoretzkiDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Maire BrasselerDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Burcin DoganDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-0182-7379
Tom HühneDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Daniel BernardDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Anne SchöneckerDepartment of Pediatrics III, Pediatric Pulmonology and Sleep Medicine, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Mathis SteindorDepartment of Pediatrics III, Pediatric Pulmonology and Sleep Medicine, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-2724-5297
Andrea GangfußDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.ORCID 0000-0002-9975-0092
Adela Della MarinaDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-0737-6142
Ursula Felderhoff-MüserDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Christian Dohna-SchwakeDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.
Nora BrunsDepartment of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147 Essen, Germany.ORCID 0000-0003-3809-1887
University of Duisburg-Essen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong COVID (LC) is a diagnosis that requires exclusion of alternative somatic and mental diseases. The aim of this study was to examine the prevalence of differential diagnoses in suspected pediatric LC patients and assess whether adult LC symptom clusters are applicable to pediatric patients. MATERIALS AND

methodsPediatric presentations at the Pediatric Infectious Diseases Department of the University Hospital Essen (Germany) were assessed retrospectively. The correlation of initial symptoms and final diagnoses (LC versus other diseases or unclarified) was assessed. The sensitivity, specificity, negative and positive predictive values of adult LC symptom clusters were calculated.

resultsOf 110 patients, 32 (29%) suffered from LC, 52 (47%) were diagnosed with alternative somatic/mental diseases, and 26 (23%) remained unclarified. Combined neurological and respiratory clusters displayed a sensitivity of 0.97 (95% CI 0.91-1.00) and a negative predictive value of 0.97 (0.92-1.00) for LC. DISCUSSION/

conclusionsThe prevalence of alternative somatic and mental diseases in pediatric patients with suspected LC is high. The range of underlying diseases is wide, including chronic and potentially life-threatening conditions. Neurological and respiratory symptom clusters may help to identify patients that are unlikely to be suffering from LC.

Indexed as

COVID-19Post-Acute COVID-19 SyndromeAdolescentAdultChildCohort StudiesHumansPrevalenceRetrospective Studiesdifferential diagnosespediatric Long COVIDpost-acute sequelae SARS-CoV-2 infectionpost COVIDsymptom cluster

Identifiers

PMID36851793
PMCPMC9961131
OpenAlexW4321373350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.