ArticleViruses2023
Introductions of Human-Origin Seasonal H3N2, H1N2 and Pre-2009 H1N1 Influenza Viruses to Swine in Brazil.
Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic Models of Influenza Transmission in Commercial Swine Populations: A Systematic Review.Pathogens (Basel, Switzerland) · 2024Pooled it
- Human-Origin Influenza A(H3N2) Viruses Revealed in Swine Farms During the Period 2022-2025 in Kazakhstan.Animals : an open access journal from MDPI · 2026Article
- Influenza virus infection during pregnancy: a review of risk factors, pathogenic mechanisms, and prevention strategies.Frontiers in immunology · 2026Review
- Passive surveillance for Influenza A virus among swine, Brazil, 2009-2023.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Fecal and Environmental Shedding of Influenza A Virus in Brazilian Swine: Genomic Evidence of Recent Human-to-Swine Transmission.Pathogens (Basel, Switzerland) · 2025Article
- Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023.Nature communications · 2024Article
- Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control.Emerging microbes & infections · 2024Article
- Review
- Novel introductions of human-origin H3N2 influenza viruses in swine, Chile.Frontiers in veterinary science · 2024Article
- A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs.Virology journal · 2023Article
- Human Seasonal Influenza Viruses in Swine Workers in Lagos, Nigeria: Consequences for Animal and Public Health.Viruses · 2023Article
- Human-to-swine introductions and onward transmission of 2009 H1N1 pandemic influenza viruses in Brazil.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In South America, the evolutionary history of influenza A virus (IAV) in swine has been obscured by historically low levels of surveillance, and this has hampered the assessment of the zoonotic risk of emerging viruses. The extensive genetic diversity of IAV in swine observed globally has been attributed mainly to bidirectional transmission between humans and pigs. We conducted surveillance in swine in Brazil during 2011-2020 and characterized 107 H1N1, H1N2, and H3N2 IAVs. Phylogenetic analysis based on HA and NA segments revealed that human seasonal IAVs were introduced at least eight times into swine in Brazil since the mid-late 1980s. Our analyses revealed three genetic clades of H1 within the 1B lineage originated from three distinct spillover events, and an H3 lineage that has diversified into three genetic clades. The N2 segment from human seasonal H1N2 and H3N2 viruses was introduced into swine six times and a single introduction of an N1 segment from the human H1N1 virus was identified. Additional analysis revealed further reassortment with H1N1pdm09 viruses. All these introductions resulted in IAVs that apparently circulate only in Brazilian herds. These results reinforce the significant contributions of human IAVs to the genetic diversity of IAV in swine and reiterate the importance of surveillance of IAV in pigs.
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