Evidence map›Paper›PMID 36851749›Full record

ArticleViruses2023

Characterization of Influenza A(H1N1)pdm09 Viruses Isolated in the 2018-2019 and 2019-2020 Influenza Seasons in Japan.

Takuma Soga, Calvin Duong, David Pattinson, Yuko Sakai-Tagawa, Akifumi Tokita, Naomi Izumida, Tamon Nishino, Haruhisa Hagiwara, Noriyuki Wada, Yumi Miyamoto and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Takuma SogaDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Calvin DuongDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0002-5020-0727
David PattinsonDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-0001-8203
Yuko Sakai-TagawaDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0002-7261-4648
Akifumi TokitaTokyo Pediatric Association Public Health Committee, Saitama 331-0815, Japan.
Naomi IzumidaTokyo Pediatric Association Public Health Committee, Saitama 331-0815, Japan.
Tamon NishinoTokyo Pediatric Association Public Health Committee, Saitama 331-0815, Japan.
Haruhisa HagiwaraTokyo Pediatric Association Public Health Committee, Saitama 331-0815, Japan.
Noriyuki WadaTokyo Pediatric Association Public Health Committee, Saitama 331-0815, Japan.
Yumi MiyamotoSuitengumaeikiiki Clinic, Tokyo 103-0014, Japan.
Haruo KurokiSotobo Child Clinic, Chiba 299-4503, Japan.
Yuka HayashiSaitama Citizens Medical Center, Saitama 331-0054, Japan.
Masafumi SekiDivision of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan.ORCID 0000-0001-5414-8148
Natsuko KasuyaNakagawa Ekimae Naika Clinic, Kanagawa 224-0001, Japan.
Michiko KogaDivision of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0002-3122-9735
Eisuke AdachiDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of the Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0002-1623-873X
Kiyoko Iwatsuki-HorimotoDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.
Hiroshi YotsuyanagiDepartment of Infectious Diseases and Applied Immunology, IMSUT Hospital of the Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0001-7882-5262
Seiya YamayoshiDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.ORCID 0000-0001-7768-5157
Yoshihiro KawaokaDivision of Virology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

Funding

NIAID NIH HHS HHSN272201400008C
6 · The paper itself

Abstract

The influenza A(H1N1)pdm09 virus that emerged in 2009 causes seasonal epidemic worldwide. The virus acquired several amino acid substitutions that were responsible for antigenic drift until the 2018-2019 influenza season. Viruses possessing mutations in the NA and PA proteins that cause reduced susceptibility to NA inhibitors and baloxavir marboxil, respectively, have been detected after antiviral treatment, albeit infrequently. Here, we analyzed HA, NA, and PA sequences derived from A(H1N1)pdm09 viruses that were isolated during the 2018-2019 and 2019-2020 influenza seasons in Japan. We found that A(H1N1)pdm09 viruses possessing the D187A and Q189E substitutions in HA emerged and dominated during the 2019-2020 season; these substitutions in the antigenic site Sb, a high potency neutralizing antibody-eliciting site for humans, changed the antigenicity of A(H1N1)pdm09 viruses. Furthermore, we found that isolates possessing the N156K substitution, which was predicted to affect the antigenicity of A(H1N1)pdm09 virus at the laboratory level, were detected at a frequency of 1.0% in the 2018-2019 season but 10.1% in the 2019-2020 season. These findings indicate that two kinds of antigenically drifted viruses-N156K and D187A/Q189E viruses-co-circulated during the 2019-2020 influenza season in Japan.

Indexed as

Influenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza, HumanHumansJapanSeasonsantigenic changeantigenicityferretH1N1pdm09humaninfluenza A virus

Identifiers

PMID36851749
PMCPMC9968111

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.