Evidence map›Paper›PMID 36851681›Full record

ArticleViruses2023

Pet Rats as the Likely Reservoir for Human Seoul Orthohantavirus Infection.

Elisa Heuser, Stephan Drewes, Jakob Trimpert, Dusan Kunec, Calvin Mehl, Marieke P de Cock, Ankje de Vries, Christiane Klier, Martin Oskamp, Peter Tenhaken and 13 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [Viral zoonoses in Germany: a One Health perspective].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 5 countries.

Elisa HeuserInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, Germany.
Stephan DrewesInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, Germany.ORCID 0000-0003-1240-147X
Jakob TrimpertInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.ORCID 0000-0003-1616-0810
Dusan KunecInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.
Calvin MehlInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, Germany.ORCID 0000-0002-1885-7673
Marieke P de CockCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.ORCID 0000-0002-0940-1180
Ankje de VriesCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.ORCID 0000-0002-3242-3900
Christiane KlierDepartment of Infectious Diseases, Public Health Agency of Lower Saxony, 30449 Hannover, Germany.
Martin OskampHealth Department of Grafschaft Bentheim County, 48527 Nordhorn, Germany.
Peter TenhakenHealth service for the district and city of Osnabrück, 49082 Osnabrück, Germany.
Fatima HashemiVeterinary Department, NovaTec Immundiagnostica GmbH, 64859 Dietzenbach, Germany.
Daniela HeinzVeterinary Department, NovaTec Immundiagnostica GmbH, 64859 Dietzenbach, Germany.
Mariana NascimentoInstitute of Virology, Department of Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.ORCID 0000-0002-2208-9566
Marc BoelhauveDepartment of Agriculture, South Westphalia University of Applied Sciences, 59494 Soest, Germany.ORCID 0000-0002-7961-9425
Rasa Petraityte-BurneikieneInstitute of Biotechnology, Life Sciences Center, Vilnius University, LT-10257 Vilnius, Lithuania.ORCID 0000-0001-5676-2993
Dina RaafatInstitute of Immunology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-3610-9863
Miriam MaasCentre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, The Netherlands.ORCID 0000-0003-0122-106X
Detlev H KrügerInstitute of Virology, Charité-University Medicine Berlin, 10117 Berlin, Germany.
Andreas LatzVeterinary Department, NovaTec Immundiagnostica GmbH, 64859 Dietzenbach, Germany.ORCID 0000-0002-1999-7168
Jörg HofmannInstitute of Virology, Charité-University Medicine Berlin, 10117 Berlin, Germany.
Gerald HeckelInstitute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland.
Johannes DreesmanDepartment of Infectious Diseases, Public Health Agency of Lower Saxony, 30449 Hannover, Germany.ORCID 0000-0002-3382-495X
Rainer G UlrichInstitute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, 17493 Greifswald, Germany.ORCID 0000-0002-5620-1528
Friedrich-Loeffler-Institut · DEFreie Universität Berlin · DEImmundiagnostik (Germany) · DENational Institute for Public Health and the Environment · NLCharité - Universitätsmedizin Berlin · DEOsnabrück University · DESouth Westphalia University of Applied Sciences · DEUniversitätsmedizin Greifswald · DEUniversity of Bern · CHVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seoul orthohantavirus (SEOV) is a rat-associated zoonotic pathogen with an almost worldwide distribution. In 2019, the first autochthonous human case of SEOV-induced hemorrhagic fever with renal syndrome was reported in Germany, and a pet rat was identified as the source of the zoonotic infection. To further investigate the SEOV reservoir, additional rats from the patient and another owner, all of which were purchased from the same vendor, were tested. SEOV RNA and anti-SEOV antibodies were found in both of the patient's rats and in two of the three rats belonging to the other owner. The complete coding sequences of the small (S), medium (M), and large (L) segments obtained from one rat per owner exhibited a high sequence similarity to SEOV strains of breeder rat or human origin from the Netherlands, France, the USA, and Great Britain. Serological screening of 490 rats from breeding facilities and 563 wild rats from Germany (2007-2020) as well as 594 wild rats from the Netherlands (2013-2021) revealed 1 and 6 seropositive individuals, respectively. However, SEOV RNA was not detected in any of these animals. Increased surveillance of pet, breeder, and wild rats is needed to identify the origin of the SEOV strain in Europe and to develop measures to prevent transmission to the human population.

Indexed as

Seoul virusZoonosesAnimalsBreedingEuropeExonsFranceHumansRatsRNARNAcomplete coding sequenceshigh-throughput sequencingNorway ratpet ratrat surveillanceSeoul viruszoonoses

Identifiers

PMID36851681
PMCPMC9962845
OpenAlexW4319599824

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.