Evidence map›Paper›PMID 36851671›Full record

ArticleViruses2023

Molecular and Genetic Characterization of Hepatitis B Virus (HBV) among Saudi Chronically HBV-Infected Individuals.

Mariantonietta Di Stefano, Giuseppina Faleo, Thomas Leitner, Wei Zheng, Yang Zhang, Amna Hassan, Marwan J Alwazzeh, Josè R Fiore, Mona Ismail, Teresa A Santantonio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mariantonietta Di StefanoDepartment of Clinical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-8814-0953
Giuseppina FaleoDepartment of Clinical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-5969-3890
Thomas LeitnerTheoretical Biology & Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.ORCID 0000-0001-8160-2588
Wei ZhengDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2984-9003
Yang ZhangDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Amna HassanDivision of Gastroenterology, King Fahd Hospital of the University, Al-Khobar 31952, Saudi Arabia.
Marwan J AlwazzehCollege of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi Arabia.ORCID 0000-0002-4646-6717
Josè R FioreDepartment of Clinical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.
Mona IsmailDivision of Gastroenterology, King Fahd Hospital of the University, Al-Khobar 31952, Saudi Arabia.ORCID 0000-0001-6371-3997
Teresa A SantantonioDepartment of Clinical and Surgical Sciences, Section of Infectious Diseases, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-4342-6904
University of Foggia · ITKing Fahd Hospital of the University · SAUniversity of Michigan · USLos Alamos National Laboratory · US

Funding

Reconstructing HIV Epidemics from HIV PhylogeneticsR01AI087520 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI Thomas K. Leitner · 2010 to 2026
$11.2M
NIAID NIH HHS R01 AI087520
6 · The paper itself

Abstract

The study aimed to characterize the genotype and subgenotypes of HBV circulating in Saudi Arabia, the presence of clinically relevant mutations possibly associated with resistance to antivirals or immune escape phenomena, and the possible impact of mutations in the structural characteristics of HBV polymerase. Plasma samples from 12 Saudi Arabian HBV-infected patients were analyzed using an in-house PCR method and direct sequencing. Saudi patients were infected with mainly subgenotype D1. A number of mutations in the RT gene (correlated to antiviral resistance) and within and outside the major hydrophilic region of the S gene (claimed to influence immunogenicity and be related to immune escape) were observed in almost all patients. Furthermore, the presence of mutations in the S region caused a change in the tertiary structure of the protein compared with the consensus region. Clinical manifestations of HBV infection may change dramatically as a result of viral and host factors: the study of mutations and protein-associated cofactors might define possible aspects relevant for the natural and therapeutic history of HBV infection.

Indexed as

Hepatitis BHepatitis B virusAntiviral AgentsConsensusHumansSaudi ArabiaAntiviral Agentsgenotype DHBsAgHBV resistancehepatitis B virus (HBV)major hydrophilic region (MHR)

Identifiers

PMID36851671
PMCPMC9964524
OpenAlexW4319442035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.