Evidence map›Paper›PMID 36851601›Full record

ArticleViruses2023

Repetitive Exposure to Bacteriophage Cocktails against

Chantal Weissfuss, Sandra-Maria Wienhold, Magdalena Bürkle, Baptiste Gaborieau, Judith Bushe, Ulrike Behrendt, Romina Bischoff, Imke H E Korf, Sarah Wienecke, Antonia Dannheim and 7 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Phage-induced protection against lethal bacterial reinfection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Viruses · 2024
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Chantal WeissfussCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.ORCID 0000-0003-3701-3190
Sandra-Maria WienholdCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.
Magdalena BürkleCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.ORCID 0000-0002-4767-2942
Baptiste GaborieauInstitut Pasteur, Université Paris Cité, CNRS UMR6047, Department of Microbiology, Bacteriophage Bacteria Host, 75015 Paris, France.ORCID 0000-0002-9586-3014
Judith BusheDepartment of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany.ORCID 0000-0001-6103-3277
Ulrike BehrendtCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.
Romina BischoffCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.ORCID 0000-0001-7008-405X
Imke H E KorfDepartment of Pharmaceutical Biotechnology, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 38124 Braunschweig, Germany.ORCID 0000-0001-6073-9307
Sarah WieneckeDepartment of Pharmaceutical Biotechnology, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 38124 Braunschweig, Germany.
Antonia DannheimDepartment of Pharmaceutical Biotechnology, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 38124 Braunschweig, Germany.
Holger ZiehrDepartment of Pharmaceutical Biotechnology, Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 38124 Braunschweig, Germany.
Christine RohdeDepartment of Microorganisms, Leibniz Institute DSMZ, German Collection of Microorganisms and Cell Cultures GmbH, 38124 Braunschweig, Germany.
Achim D GruberDepartment of Veterinary Pathology, Freie Universität Berlin, 14163 Berlin, Germany.ORCID 0000-0002-4502-0393
Jean-Damien RicardUniversité Paris Cité, INSERM UMR1137, IAME, 75018 Paris, France.ORCID 0000-0003-1828-2299
Laurent DebarbieuxInstitut Pasteur, Université Paris Cité, CNRS UMR6047, Department of Microbiology, Bacteriophage Bacteria Host, 75015 Paris, France.ORCID 0000-0001-6875-5758
Martin WitzenrathCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.ORCID 0000-0002-9787-5633
Geraldine NouaillesCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases, Respiratory Medicine and Critical Care, 10117 Berlin, Germany.ORCID 0000-0003-1973-3119
Humboldt-Universität zu Berlin · DEFraunhofer Institute for Toxicology and Experimental Medicine · DECentre National de la Recherche Scientifique · FRFreie Universität Berlin · DEInserm · FRLeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern. In this study, we investigated the innate and adaptive immune responses to two different phage cocktails targeting either

Indexed as

BacteriophagesImmunity, HumoralAnimalsEscherichia coliMiceMice, Inbred C57BLPseudomonas aeruginosaadaptive and innate immunityimmunogenicityphage therapypneumonia

Identifiers

PMID36851601
PMCPMC9964535
OpenAlexW4318478644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.