Evidence map›Paper›PMID 36851495›Full record

ArticleViruses2023

Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses.

Kassandra L Carpio, Jill K Thompson, Steven G Widen, Jennifer K Smith, Terry L Juelich, David E Clements, Alexander N Freiberg, Alan D T Barrett

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Langat Virus Biology and Infection.Reviews in medical virology · 2026
    Review
  3. LRP8 is an entry receptor for tick-borne encephalitis viruses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Tick-borne zoonotic flaviviruses andOne health (Amsterdam, Netherlands) · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kassandra L CarpioDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jill K ThompsonDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Steven G WidenDepartment of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Jennifer K SmithDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Terry L JuelichDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
David E ClementsHawaii Biotech Inc., Honolulu, HI 96817, USA.
Alexander N FreibergDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8413-8960
Alan D T BarrettDepartment of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-3740-7448
The University of Texas Medical Branch at Galveston · USHawaii Biotech (United States) · US

Funding

Hawaii Biotech COVID-19 Response to PA-18-591R44AI118017 · NIAID · HAWAII BIOTECH, INC. · PI CLEMENTS, DAVID E · 2015 to 2021
$5.2M
NIAID NIH HHS R44 AI118017
6 · The paper itself

Abstract

The genetic diversities of mammalian tick-borne flaviviruses are poorly understood. We used next-generation sequencing (NGS) to deep sequence different viruses and strains belonging to this group of flaviviruses, including Central European tick-borne encephalitis virus (TBEV-Eur), Far Eastern TBEV (TBEV-FE), Langat (LGTV), Powassan (POWV), Deer Tick (DTV), Kyasanur Forest Disease (KFDV), Alkhurma hemorrhagic fever (AHFV), and Omsk hemorrhagic fever (OHFV) viruses. DTV, AHFV, and KFDV had the lowest genetic diversity, while POWV strains LEIV-5530 and LB, OHFV, TBEV-Eur, and TBEV-FE had higher genetic diversities. These findings are compatible with the phylogenetic relationships between the viruses. For DTV and POWV, the amount of genetic diversity could be explained by the number of tick vector species and amplification hosts each virus can occupy, with low diversity DTV having a more limited vector and host pool, while POWV with higher genetic diversities has been isolated from different tick species and mammals. It is speculated that high genetic diversity may contribute to the survival of the virus as it encounters these different environments.

Indexed as

Encephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneAnimalsGenetic VariationMammalsPhylogenyAlkhurma hemorrhagic fever virusDeer Tick virusFar Eastern tick-borne encephalitis virusflavivirusgenetic diversityKyasanur Forest Disease virusLangat virusOmsk hemorrhagic fever virusPowassan virustick-borne encephalitis virustick-borne viruses

Identifiers

PMID36851495
PMCPMC9959157
OpenAlexW4317423689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.