ReviewViruses2023
Immune and Metabolic Alterations in Children with Perinatal HIV Exposure.
Review in Viruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Evaluating Risk of Tuberculosis Infection and Disease Among Adolescents Who Are HIV-exposed Uninfected in Botswana.The Pediatric infectious disease journal · 2026Article
- Persistent neuroimmune alterations in children who are HIV-exposed but uninfected at age 6-7 years: Associations with language development in a South African birth cohort.bioRxiv : the preprint server for biology · 2026Article
- Infectious morbidity among children HIV-exposed uninfected in South Africa.AIDS (London, England) · 2026Article
- The Effects of In Utero HIV and Antiretroviral Therapy Exposure on Infant T-Cell and Monocyte Activation, Function, and Regulation of Immune-Modulatory Pathways.Mediators of inflammation · 2026Article
- Characterizing immune activation in HIV-exposed but uninfected infants in the first year of life.Frontiers in immunology · 2026Observational
- A Longitudinal Study of Baseline Fatty Acid Concentrations and Executive Function Over 12 Months Among Adolescents With and Without Perinatal HIV Exposure or Infection From Kampala, Uganda.The Journal of nutrition · 2025Article
- Review
- Review
- Maternal and child immune profiles are associated with neurometabolite measures of early-life neuroinflammation in children who are HIV-exposed and uninfected: a South African birth cohort.Wellcome open research · 2025Article
- Mortality rates in a cohort of infants attending immunization clinics in Uganda (2017-2019).PloS one · 2025Observational
- Risk factors of under-five and infant mortality: An umbrella review of systematic reviews and meta-analyses.Journal of global health · 2024Review
- Hepatitis A Seroprevalence Among HIV-Exposed and Unexposed Pediatric Populations in South Africa.Vaccines · 2024Article
- Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed infants.iScience · 2024Article
- Metabolic Alterations in Mothers Living with HIV and Their HIV-Exposed, Uninfected Infants.Viruses · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the global rollout of mother-to-child prevention programs for women living with HIV, vertical transmission has been all but eliminated in many countries. However, the number of children who are exposed in utero to HIV and antiretroviral therapy (ART) is ever-increasing. These children who are HIV-exposed-but-uninfected (CHEU) are now well recognized as having persistent health disparities compared to children who are HIV-unexposed-and-uninfected (CHUU). Differences reported between these two groups include immune dysfunction and higher levels of inflammation, cognitive and metabolic abnormalities, as well as increased morbidity and mortality in CHEU. The reasons for these disparities remain largely unknown. The present review focuses on a proposed link between immunometabolic aberrations and clinical pathologies observed in the rapidly expanding CHEU population. By drawing attention, firstly, to the significance of the immune and metabolic alterations observed in these children, and secondly, the impact of their healthcare requirements, particularly in low- and middle-income countries, this review aims to sensitize healthcare workers and policymakers about the long-term risks of in utero exposure to HIV and ART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.